At Covant Therapeutics, our mission is to treat diseases with first-and best-in-class covalent therapeutics for the most significant drug targets by leveraging our cutting-edge capabilities and expertise in chemistry, quantitative proteomics, translational sciences, and deep learning.
We continuously strive to advance science at a fast pace, helping and supporting each other in the discovery of new medicines that can provide transformative benefits to patients. The successful candidate will be part of a collaborative team of scientists with expertise in covalent drug discovery charged with rapidly expanding our portfolio of drug discovery programs.
Job Responsibilities
We are currently seeking a Director/Senior Director, Drug Metabolism and Pharmacokinetics, who will have scientific oversight of our portfolio and will manage the in vitro and in vivo PK, ADME and bioanalytical assays. The candidate will be expected to collaborate with our cross-functional drug discovery teams to develop and implement studies vital to address key program DMPK issues and successfully advance research compounds into development.
- Lead scientific efforts to characterize pharmacokinetic properties of drug candidates (small molecule and peptides) to inform and direct lead optimization of drug candidates.
- Provide scientific DMPK leadership and strategic direction to research project teams with experience mentoring and guiding junior scientists.
- Scientific supervision of PK studies conducted at CROs.
- Implement/manage quantitative bioanalysis of plasma and other biological matrices to support pharmacokinetic, toxicokinetics, and in vitro ADME analyses of novel small molecule and peptide therapeutics.
- Conduct PK and PK/PD modeling using non-compartmental and compartmental models.
Basic Requirements:
- PhD in a relevant scientific field
- 7-10+ years of work experience in Drug Discovery/ DMPK
Additional Skills/Preferences:
- Strong publication record in the area of ADME/PK coupled with a high level of scientific curiosity and analytical thinking skills.
- Prior success demonstrating strong leadership, collaboration and influence throughout the organization.
- Prior management experience is a plus.
- Experience in coordination of in vitro metabolism, DDI, transporters and/or protein binding studies
- Experience in performing or supervising the execution of bioanalytical assays and the development of such assays.
- Capable of working autonomously and collaboratively in a multidisciplinary team setting
- Strong verbal, written communication and relationship skills including success managing external vendors.
- Excellent interpersonal and organizational skills
- Success operating in a fast-paced, dynamic environment.
Covant Therapeutics provides equal employment opportunities to all employees and applicants for employment and prohibits discrimination and harassment of any type without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws.
