Company Overview
At Clasp Therapeutics, we are revitalizing immuno-oncology’s promise with next-generation T cell engagers (TCEs). Our novel TCE therapeutics enable a patient’s T cells to identify and specifically destroy tumor cells with absolute precision. Our medicines’ high level of precision and specificity essentially eliminate the likelihood of on-target off-tumor toxicities that have occurred with other TCEs. We have targeted our molecules to hard-to-treat tumors bearing common cancer driver mutations. Our specific platform structure targets mutated protein fragments, or peptides, that are displayed by specialized HLA and are designed to draw T cells into close contact with tumor cells. The resulting immune synapse is highly similar to a natural HLA molecule-T cell receptor interface with a high level of sensitivity, triggering T cells to destroy tumor cells. This approach enables a highly genetically selective paradigm where every patient has the opportunity to respond to treatment.
Founded in 2020, we are focused on bringing the outstanding science from our world-class founders to patients. In 2023, Clasp closed a $150 million Series A financing round led by Catalio Capital Management, Third Rock Ventures, and Novo Holdings. Clasp has created a vibrant culture with people who are committed to our mission in both our Cambridge, MA, and Rockville, MD sites.
Position Summary
Clasp Therapeutics is seeking a Scientist to help drive our novel immunotherapy programs. We are searching for an enthusiastic, innovative scientist with a background in immunology and experience in cell-based assays, who will thrive in our fast-paced, entrepreneurial, collaborative environment. The candidate must be goal oriented, flexible, and able to work efficiently across multiple projects in a matrixed environment. We are looking for team members who are motivated by the opportunity to build something new and to be part of creating an exciting fun place to work.
Responsibilities
- Develop functional cell-basedin vitro assays with primary human cells to select drug candidates and investigate their mechanism of action.
- Design immunophenotyping panels and perform multicolor flow cytometry.
- Evaluate cytokine and analyte expression using ELISA, AlphaLISA, or MSD assays.
- Isolate and characterize immune cells, particularly T cells.
- Plan, perform, analyze, interpret and report results from the studies with minimal supervision.
- Design, perform, interpret and report in vitro assays to support IND application.
- Work with others in the design, execution and analysis of in vivo experiments including proof of concept studies.
- Document data in electronic laboratory notebook and write technical reports.
- Communicate directly results to internal stakeholders and at program team meetings.
- Other duties, as assigned.
Qualifications
- PhD in biology or related discipline; post-doc experience a plus
- Hands-on experience with multicolor flow cytometry, primary hematopoietic cell isolation and cell-based functional assays
- Molecular biology skills preferred
- Strong background in immunology highly preferred
- Capability to anticipate and recognize potential issues within experimental designs and effectively identify and communicate alternatives
- Motivated to find solutions and drive to results; willing to use the same energy to ensure the success of everyone in the team
- Ability to communicate clearly in writing and orally; excellent record keeping abilities to document analytical data generated in support of regulatory requirements
- Ability to manage multiple projects, prioritize work and meet tight deadlines
- Strong interpersonal skills to foster an open and collaborative environment
- Enjoys being part of a fun and motivated team that is focused on making a difference for patients
Clasp Therapeutics is an equal opportunity employer committed to fostering an inclusive and diverse workplace. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, nationality, national or ethnic origin, civil status, age, citizenship status, sexual orientation, disability, marital or registered civil partnership status, pregnancy or parental status, gender identity, military or veteran status, or any other protected characteristic in accordance with applicable laws and regulations. We will ensure that individuals with disabilities are provided reasonable accommodations to participate in the job application process. Please contact us to discuss any accommodations you may need.
Note to Employment Agencies: Please, no phone calls or emails to any employee of Clasp Therapeutics about our openings. All resumes submitted by search firms/employment agencies to any employee at Clasp Therapeutics via email, the internet or in any form and/or method will be deemed the sole property of Clasp Therapeutics, unless such search firms/employment agencies were engaged for the position and a valid agreement is in place. In the event a candidate is hired who was submitted outside the Clasp Therapeutics agency engagement process, no fee or payment of any kind will be paid.
