Centrillion Biosciences is developing cutting edge genomic technologies. We have advanced research laboratories in Palo Alto, CA; Portland, OR; Hangzhou, China and Hsinchu, Taiwan for conducting research in bioinformatics, genomics, chemistry, biochemistry, and molecular biology.  The following position is for our Palo Alto facility. Centrillion Biosciences is seeking a highly motivated and skilled Research Scientist – Nucleic Acids Chemistry to join our chemistry team.


  • Plan and execute applied research experiments involving: Synthesis, modification and characterization of modified nucleotides, nucleoside polyphosphates and oligonucleotides
  • Preparation of fluorescent dye conjugates of nucleotides and oligonucleotides.
  • Materials modification and characterization for solid phase synthesis
  • Collaborate with and/or supervise other scientists & engineers on joint projects.
  • Documentation of experimental work; analysis of data; documenting and presenting results
  • Preparation of written methods and SOPs
  • Operation and maintenance of laboratory & analytical equipment
  • Support R&D and Pilot Manufacturing Operations and QC


  • Ph.D. in organic chemistry, with extensive training and practical laboratory experience in organic synthesis, physical organic and bio-organic chemistry.
  • Experience with nucleoside, nucleotide, and solid-phase oligonucleotide synthesis.
  • Experience preparing fluorescent dye conjugates of nucleotides and oligonucleotides.
  • Proficient in the use of methods of instrumental chemical analysis, such as NMR, HPLC, MS, FTIR, is essential.
  • Working knowledge and practical experience with polymer and surface chemistry is strongly desired.
  • Demonstrated ability to plan and execute independent and collaborative research projects.
  • Demonstration of goal-oriented, hands-on and innovative approach to problem solving.
  • Co-authorship on one or more publications in peer-reviewed scientific journals.
  • She/he will be required to develop additional competencies, and apply practical skills and knowledge to solving a variety of applied scientific and technical problems.

All applicants, please send publication list and any additional description of research experience, like, manuscripts, abstracts and meeting presentations, with your application.

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