Caribou is a leading clinical-stage CRISPR genome-editing biopharmaceutical company founded by pioneers in this field. Leveraging our proprietary technologies, we are developing genome-edited, off-the-shelf immune cell therapies for the treatment of patients with devastating human diseases, including cancer. We believe that cell therapies are critical now and for the future of cancer therapeutics, and that advanced genome editing is necessary to develop sophisticated cell therapies to treat a variety of malignancies. We are developing a pipeline of wholly-owned, genome-edited, off-the-shelf CAR-T and CAR-NK cell therapy product candidates for a range of tumor types. Caribou’s headquarters are in Berkeley, California.
Members of the Caribou herd open their minds to new ideas and welcome diverse perspectives. We proudly assert that teams do their best work when their members are personally engaged, their ideas are taken seriously, their contributions are recognized, and their needs are met.
As a result of exciting developments both with Caribou’s internal pipeline programs and with our external partnership, we have multiple early-stage projects at Caribou focused on the preclinical discovery and development of CAR-T cell therapy candidates. We are looking for an independent, goal-oriented Scientist to help us propel this work forward. In this exciting and challenging role, you will support early stage preclinical programs using genome editing technologies, T cell biology and immunology to develop novel CAR T cell therapies. The ideal motivated and enthusiastic candidate will join a highly dynamic and collaborative environment, working cross-functionally with multiple researchers on cutting-edge technologies to deliver on impactful research projects that we believe will ultimately positively impact the lives of patients.
- Working with a matrixed team to develop and advance preclinical allogeneic CAR-T cell programs targeting liquid and/or solid tumors
- Developing and troubleshooting in vitro functional assays for the characterization of allogeneic CAR-T cell therapy candidates
- Designing, coordinating, and executing in vitro and ex vivo immunology experiments
- Analyzing/interpreting data and communicating the results clearly and promptly
- Keeping detailed, organized, and accurate records of experiments and results
- Staying current on primary literature
- PhD in immunology, molecular biology, cell biology, or a closely related field with 0-3 years of post doc
- Experience in planning and executing in vitro functional assays to characterize primary immune cells including, but not limited to, cytotoxicity assays, cytokine/chemokine measurements, and proliferation assessment
- Experience in multi-parameter flow cytometry and data analysis
- Ability to work independently and as part of a team
- Excellent interpersonal, verbal, and written communication skills are essential in our collaborative research environment
- Work in pharmaceutical or biotechnology company focused on immuno-oncology
- Primary cell culture
- Experience evaluating therapeutic candidates in animal models
- Experience writing technical reports
- Understanding of regulatory guidelines for cell therapies
Caribou compensation and benefits include:
- Comprehensive compensation package, which includes stock options and an employee stock purchase program for all employees
- Generous paid vacation time, in addition to company-observed holidays and floating holidays
- Excellent medical, dental, and vision insurance
- 401(k) retirement savings plan, which includes matching employer contributions
- Tuition reimbursement program
Caribou is an equal opportunity employer and does not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws. Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.
Caribou requires employees to be fully vaccinated, including a booster shot, against COVID-19 unless they have an approved medical or religious accommodation. Proof of such vaccination will be required as part of the hiring process.
For more information about Caribou, visit www.cariboubio.com and follow the company @CaribouBio.