Caribou is a leading clinical-stage CRISPR genome-editing biopharmaceutical company founded by pioneers in this field. Leveraging our proprietary technologies, we are developing genome-edited, off-the-shelf immune cell therapies for the treatment of patients with devastating human diseases, including cancer. We believe that cell therapies are critical now and for the future of cancer therapeutics, and that advanced genome editing is necessary to develop sophisticated cell therapies to treat a variety of malignancies. We are developing a pipeline of wholly-owned, genome-edited, off-the-shelf CAR-T and CAR-NK cell therapy product candidates for a range of tumor types. Caribou’s headquarters are in Berkeley, California.

Members of the Caribou herd open their minds to new ideas and welcome diverse perspectives. We proudly assert that teams do their best work when their members are personally engaged, their ideas are taken seriously, their contributions are recognized, and their needs are met. 

As a result of exciting developments both with Caribou’s internal pipeline programs and with the addition of external partnership, we have multiple early-stage projects at Caribou focused on the preclinical discovery and development of CAR-T cell therapy candidates. We are looking for an independent, goal-oriented Research Associate/Senior Research Associate to help us propel this work forward. This is an exciting and challenging role in which you will lend your molecular and cell biology expertise to support a variety of research and development projects. You will work collaboratively and cross-functionally with multiple researchers on cutting-edge technologies with progressive ideas to deliver on impactful research projects that we believe will ultimately positively impact the lives of patients.

Responsibilities include:

  • Designing and performing an array of molecular biology techniques including primer design, PCR, in vitro transcription, plasmid design and cloning, small- and large-scale plasmid preparation
  • Culturing primary human T cells & stem cells, including isolation, activation and expansion from peripheral blood mononuclear cells
  • Gene editing and manipulation of primary cells using nucleofection and viral transduction
  • Analyzing gene editing outcomes by sequencing and flow-based methodologies
  • Coordinating experiments with other Scientists and RAs across functional groups
  • Compiling data, presenting results, and staying current on relevant literature

Qualifications:

  • Bachelor’s degree, Master’s degree or equivalent experience in Cell Biology, Immunology, Biochemistry, Molecular Biology, or related discipline
  • Minimum of 2 years of experience designing and performing molecular and cell assays
  • Experience with a variety of molecular techniques such as PCR, cloning, and in vitro transcription
  • Experience in mammalian cell culture techniques
  • Data analysis experience
  • Willingness and ability to share occasional weekend cell culture duties

Nice-to-haves:

  • Competency in flow cytometry
  • Competency with molecular biology design tools
  • Background in immunology or oncology
  • Sequencing platforms such as NGS - lllumina, Nanopore, or PacBio
  • Application of genome editing technologies
  • Experience working with a wide array of primary cells (including iPSC and NK cells) and cell lines

Caribou compensation and benefits include:

  • Comprehensive compensation package, which includes stock options and an employee stock purchase program for all employees
  • Generous paid vacation time, in addition to company-observed holidays and floating holidays
  • Excellent medical, dental, and vision insurance
  • 401(k) retirement savings plan, which includes matching employer contributions
  • Tuition reimbursement program

Caribou is an equal opportunity employer and does not discriminate based on race, color, religion, marital status, age, national origin, ancestry, physical or mental disability, medical conditions, veteran status, sexual orientation, gender (including gender identity and gender expression), sex (which includes pregnancy, childbirth, and breastfeeding), genetic information, taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws. Legal authorization to work in the United States is required. In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire. 

Caribou requires employees to be fully vaccinated, including a booster shot, against COVID-19 unless they have an approved medical or religious accommodation. Proof of such vaccination will be required as part of the hiring process.

For more information about Caribou, visit www.cariboubio.com and follow the company @CaribouBio.

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