Director of Bioinformatics, Prenatal

Do you want to join one of the fastest-growing molecular diagnostics startups and develop products that can affect the lives of millions?

BillionToOne, ranked at the top 5% of Y Combinator companies with $300M+ in funding from prominent VC firms, has developed a DNA molecular counter that increases cfDNA diagnostic resolution by over 1,000 fold. BillionToOne's first product, UNITY™ is the first and only non-invasive prenatal test that can directly screen an unborn baby and assess its risk for common and severe recessive gene disorders and chromosomal abnormalities, as well as fetal sex and fetal antigens, from a single tube of blood from the pregnant mother without paternal testing.

In 2023, BillionToOne launched two liquid biopsy products that will markedly improve oncology treatment and care. With Northstar Select™, clinicians will be able to select cancer therapies that will be most effective to each patient based on their individual genetic makeup. Northstar Response™ will enable clinicians to monitor a patient’s early response to these cancer therapies, by measuring minute changes in their ctDNA, which can reduce ineffective treatments and unwanted toxicity, lower costs, and substantially improve clinical outcomes.

As the Director of Bioinformatics, Prenatal at BillionToOne, you will lead a dynamic team of Bioinformatics Scientists and Engineers, shaping the direction of our prenatal bioinformatics efforts. You will be responsible for developing, implementing, and supporting clinical next-generation sequencing analysis pipelines for the Unity product line. You will collaborate closely with cross-functional teams (R&D, clinical, Software Engineering, Process Engineering, Product) to support new assay development and existing assay enhancements, with a strong emphasis on scaling and workflow efficiency. This is a full-time hybrid role (at least ~40% on-site in Menlo Park or Union City locations) and reports to the VP of Lab Operations. 

Responsibilities:

• Strategic Direction: Provide strategic direction for prenatal bioinformatics efforts, aligning strategies with company goals and collaborating with cross-functional teams.
• Team Leadership: Lead the Bioinformatics team, fostering innovation, collaboration, and growth. Guide project priorities, resources, and career development.
• Innovative Strategies: Develop and execute bioinformatics strategies to enhance next-generation sequencing pipelines for the Unity product line, driving innovation.
• Quality Assurance: Establish and oversee rigorous quality control and assurance processes to ensure accurate and reliable bioinformatics results.
• Effective Collaboration: Collaborate with the CLIA laboratory, the clinical team, and R&D scientists to translate new scientific insights into actionable bioinformatics solutions supporting clinical diagnostics.
• Clear Communication: Communicate project progress and bioinformatics strategies to leadership, internal stakeholders, and external partners.

Requirements:

• PhD in Bioinformatics, Computational Biology, Computer Science, Bioengineering, Physics or related field
• Demonstrated ability to manage and lead a team of bioinformaticians.
• Excellent project management skills and attention to detail.
• Excellent communication and ability to work collaboratively with a cross-functional team
• 10+ years of bioinformatics experience (including PhD years or afterward)
• 5+ years of experience analyzing NGS data (including PhD years or afterward)
• 3+ years of experience building out and managing a team with multiple layers or functions
• Expertise in Python, R, or a similar programming language
• Experience using data structures, command-line tools, shell scripts, industry tools (GitHub, AWS, Heroku)

Nice-To-Haves:

• Experience in a clinical diagnostics laboratory

Benefits And Perks:

• Working with a team of ‘rockstars’ who bring out the best in everyone
• Open, transparent culture that includes weekly Town Hall meetings
• The ability to indirectly or directly change the lives of hundreds of thousands patients
• Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered at 80%
• Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
• Retirement savings program including a 4% Company match
• Free daily on-site lunches provided from top eateries
• Latest and greatest hardware (laptop, lab equipment, facilities)
• A variety of perks on campus (state of the art gym, restaurant)
• Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of a (1) base pay range (actual amount offered is based experience and salary/equity options split that the candidate chooses) (2) generous equity options offering, on top of (3) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave etc.).

For this position, we offer a total compensation package of $350,000 per year, including a base pay range of $200,000 to $225,000 per year.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.