BillionToOne is a next-generation molecular diagnostics company dedicated to developing powerful and accurate diagnostic tests that are accessible to all. Our innovative QCT molecular counting technology significantly enhances the resolution of disease detection using cell-free DNA by over a thousandfold. This groundbreaking technology is integral to our product offerings, including one of our flagship products, Unity Complete™, the only non-invasive prenatal screen capable of assessing fetal risk for both common recessive conditions and aneuploidies from a single maternal blood sample. Leveraging the same molecular counting technology, we've expanded our impact into oncology in 2023 with a pioneering liquid biopsy test, Northstar, that combines treatment selection with monitoring. To date, over 500,000 patients have benefited from our innovative and precise diagnostic tests, and our Annual Recurring Revenue (ARR) has grown from $0 to $125 million in the last ~4 years.

BillionToOne has successfully raised close to $400 million in funding, with a notable $130 million Series D round completed in June 2024, resulting in a company valuation of over $1 billion. This funding has come from prestigious global institutional investors, including Hummingbird, Adams Street Partners, Neuberger Berman, Baillie Gifford, and Premji Invest. BillionToOne has recently been recognized by Forbes as one of America's Best Startup Employers for 2024, highlighting the company's exceptional work environment and commitment to innovation.

Our team has grown significantly and we now proudly employ over 400 highly skilled individuals. Despite substantial growth, we have successfully maintained the unique culture that has defined BillionToOne from inception, continuing to cultivate a team that is not only diverse and passionate but also innovative. Headquartered in Menlo Park, California, with an additional facility in Union City, California, BillionToOne remains at the forefront of significant advances in molecular diagnostics, evidenced by the recent announcement of clinical outcomes data for its Unity Fetal Risk Screen and new advancements in cancer diagnostics. For more detailed information about BillionToOne and its groundbreaking work, please visit our website at

We are looking for a driven Lead Clinical Laboratory Scientist (with California Clinical Laboratory Scientist License) to support UNITY, the only non-invasive prenatal test (NIPT) that can detect inherited disorders such as sickle cell disease, spinal muscular atrophy, and cystic fibrosis in the baby directly from maternal blood. These disorders are extremely severe, but early detection and intervention can significantly improve outcomes. You will join and oversee our growing superstar CLIA team responsible for end-to-end processing of pregnancy blood samples in a high complexity, high-growth CLIA setting. The Lead Clinical Laboratory Scientist is an onsite position for Tues - Sat PM shift.


  • Lead clinical laboratory daily supervision in alignment with company values and mission
  • Hold General Supervisor delegation and responsibilities including oversight and support of day-to-day operations, scheduling, and troubleshooting
  • Manage CLIA direct reports including licensed and/or unlicensed staff (CLS, Clinical Laboratory Assistants)
  • Contribute to continuous process improvement projects including tech transfer, troubleshooting, training, and validations
  • Perform clinical laboratory assays to provide data for diagnosis, treatment, and prevention of disease
  • Perform quality control studies to ensure the accuracy of clinical data
  • Verify instrument performance by checking and calibrating specific lab instruments and documents data


  • Bachelor's degree in the chemical, physical or biological sciences
  • Minimum of 4 years of CLS experience in a clinical setting (molecular and/or high-complexity laboratory experience preferred)
  • A current California Clinical Laboratory Scientist License that meets requirements for Testing Personnel under CLIA regulations (42 CFR, part 493) (ASCP, CGMBS or generalist license is required)
  • Hands-on training and experience with manual molecular biology protocols, including DNA extraction, PCR, and automated liquid handlers
  • Advanced knowledge of Google Docs, Word, Excel, basic statistics and familiarity with LIMS systems and Next-Generation Sequencing
  • Strong attention to detail and ability to work flexibly and well under given timeframes.
  • Self-starter and dynamic team player with excellent verbal and written skills.


  • Previous CLIA General Supervisor experience
  • Start-up experience
  • Knowledge of medical genetics
  • Experience in a cell-free DNA setting

Benefits And Perks:

  • Working with a team of ‘rockstars’ who bring out the best in everyone
  • Open, transparent culture that includes weekly Town Hall meetings
  • The ability to indirectly or directly change the lives of hundreds of thousand patients
  • Multiple medical benefit options; employee premiums paid 100% of select plans, dependents covered at 80%
  • Extremely generous Family Bonding Leave for new parents (16 weeks, paid at 100%)
  • Retirement savings program including a 4% Company match
  • Free daily on-site lunches provided from top eateries
  • Latest and greatest hardware (laptop, lab equipment, facilities)
  • A variety of perks on campus (state of the art gym, restaurant)
  • Free on-site EV charging (compatible with all EVs, including Tesla)

At BillionToOne, we are proud to offer a combination of (1) competitive base pay, (2) the opportunity for professional growth, and (3) industry leading company benefits (free healthcare options, 401k match, very generous fully paid parental leave etc.).

For this position, the base pay rate is: $64-$70 per hour.

BillionToOne is an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

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