WHO WE ARE
Belharra Therapeutics is an early-stage small molecule discovery company founded by pioneers in the field of chemical biology. Through the application of our proprietary chemoproteomics platform merged with innovative biology and medicinal chemistry, we are modulating protein function in previously unidentified ways to push the limits of drug discovery. Our aim is to deliver transformative, first-in-class medicines for patients suffering from the most serious diseases.
WHAT WE ARE LOOKING FOR
Belharra is looking for a motivated Senior Associate Scientist to join our proteomics team. In this role, you’ll collaborate with chemists and biologists to create and use specialized tools for drug discovery. The successful candidate will have a background with high-throughput sample preparation and small molecule screening of large libraries. We are seeking a self-starter with strong problem-solving skills and an innovative mindset. This role will contribute to the growth of Belharra’s research portfolio by screening high value targets in a variety of cell-based assays.
WHAT YOU’LL BE RESPONSIBLE FOR
- Collaborate with the proteomics team to implement high throughput chemoproteomic platform
- Support multiple and parallel projects through high-throughput sample preparation, including probe enrichments, activity-based proteomics, MS-based quantities strategies (TMT, SILAC)
- Prioritize tasks to support multiple and parallel projects.
- Manage tissue culture demands (including multiple cancer cell or primary cell models)
Ideal Candidate:
- Master’s degree with 6+ years or bachelor’s degree with 9+ years of experience in fields like chemical biology, biochemistry, or cell biology (industry experience is a plus)
- Hands-on experience with molecular biology techniques (SDS-PAGE, western blotting)
- Extensive tissue culture experience with immortalized cell lines (suspension and adherent). Primary tissue culture experience and transient transfections is a plus.
- General understanding of quantitative proteomic data acquisition and analysis techniques (e.g., SILAC, TMT, PRM).
- Perform under tight timelines and work effectively across multiple projects and align with different project teams/ departments.
- Familiarity with high-throughput or automated instruments and assays such as the Hamilton.
- Knowledge of small-molecule target identification/ deconvolution (CETSA, DARTS and FUSION).
- Experience in complex proteomics sample preparation including immunoprecipitations, small-molecule enrichments, and whole proteome analysis.
- Proficiency with common scientific software and data analyses (Excel, PowerPoint, GraphPad)
WHAT YOU’LL BRING TO THE TEAM
- People-first approach. You take pride in the way you collaborate and partner with people across the business.
- Passion for problem solving. You are excited by new challenges and know how to achieve maximum results and drive projects forward.
- Thirst for overachieving. You don’t just meet goals, you set the standard.
- Candidate must have excellent problem-solving skills and be self-motivated.
- Strong ability to communicate with project teams through presentations and preparation of data packages.
- Clearly and accurately document work.
- Perform under tight timelines and work effectively across multiple projects and align with different project teams.
WHAT YOU’LL GET AS PART OF OUR TEAM
- A collaborative, fun, and positive culture.
- Limitless growth and learning opportunities.
- A chance to make a lasting impact on drug discovery and human health.
- Competitive compensation and company ownership.
- Excellent Medical, Dental and Vision coverage from a broad choice of providers and plans.
- 100% of Target premium coverage for employees; 85% of Target premium coverage for eligible dependents
- 401(k) program with a company sponsored contribution.
- “Take what you need” vacation and sick leave policy.
- 10 annual paid company holidays, plus the last week of December.
- A new office and lab space in San Diego with flexibility and autonomy to do your work how and where you need.
At Belharra Therapeutics, Inc. pay ranges are subject to change and are assigned to a job based on its level within the company. Individual pay within that range can vary for several reasons including skills/capabilities, experience, and available budget.
Belharra is committed to being an Equal Opportunity Employer and our policy is to provide equal employment opportunities to all applicants and employees without regard to race, color, creed, religion, sex, sexual orientation, gender identity, marital status, citizenship status, age, national origin, ancestry, disability, veteran status, or any other legally protected status and to affirmatively seek to advance the principles of equal employment opportunity.
