Arvinas is a clinical-stage biotechnology company dedicated to improving the lives of patients suffering from debilitating and life-threatening diseases through the discovery, development, and commercialization of therapies that degrade disease-causing proteins. Arvinas uses its proprietary PROTAC Discovery Engine platform to engineer proteolysis targeting chimeras, or PROTAC targeted protein degraders, that are designed to harness the body’s own natural protein disposal system to selectively and efficiently degrade and remove disease-causing proteins. In addition to its robust preclinical pipeline of PROTAC protein degraders against validated and “undruggable” targets, the company has three investigational clinical-stage programs: ARV-766 and bavdegalutamide for the treatment of men with metastatic castration-resistant prostate cancer; and vepdegestrant (ARV-471) for the treatment of patients with locally advanced or metastatic ER+/HER2- breast cancer. Arvinas, as part of its overall business strategy, selectively assesses opportunities for potential collaboration, license, marketing and royalty arrangements, and similar transactions, to advance and accelerate the development and enhance the commercial potential of its product candidates.

#TeamArvinas is made up of approximately 450 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC® protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say.

For more information, please visit www.arvinas.com. 

 

Position Summary

This key position in our functional area support team (FAST) within the platform biology group will support the discovery and characterization of PROTACs (Proteolysis-targeting chimeras) and related molecules for Arvinas research programs. This position is laboratory-based and requires strong experimental skills, and the ability to effectively partner with team members to deliver quality data in support of early drug discovery efforts.

This position will be located at our headquarters in New Haven, CT.

 

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Develop cell-based assays to support discovery and development of targeted protein degraders.
  • Execute compound profiling assays using cell-based (reporter assays, high-content screening, etc.) formats to support efforts in developing structure-activity relationships that guide lead identification and optimization for targeted protein degraders.
  • Develop and execute assays to screen compound diversity decks in a high throughput environment to identify chemical starting points for targeted protein degradation.
  • Utilize automated liquid handling systems and integrated screening platforms to acquire data with the goal of optimizing screening throughput and quality.
  • Working with senior group members and project teams, optimize assays and analyze data for storage in the corporate database and presentation at project meetings.

Qualifications

  • Experience in aseptic mammalian cell culture techniques in an industrial or academic core facility environment is required.
  • Experience in maintaining cell stocks and cryo-preservation of cell lines to assist compound screening.
  • Experience in executing cellular plate-based assays in an industrial or academic core facility environment is required.
  • Experience in running high throughput screens using automated platforms is highly desirable.
  • Experience with data analysis for high-throughput screening campaigns is highly desirable.
  • Excellent data analysis and recording skills as well as oral and written communication skills is required.
  • Innovative, motivated, researcher with strong problem solving and communication skills.
  • Demonstrable skill as key team member, building productive relationships with internal stakeholders, ability to understand complex scientific concepts.

Education

  • B.S. with 5 years of pharma/biotech or academic experience with a focus on biochemical and/or cell-based assay drug discovery.

 

#LI-New Haven, CT

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity Employer   

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