Arvinas is a clinical-stage biotechnology company leading the way in targeted protein degradation therapeutics. Arvinas is the first company to focus solely on protein degradation and its platform technology is the most advanced in the field. Since its founding in 2013, Arvinas’ PROTAC® Discovery Engine has been driving the most significant breakthroughs in the industry. Arvinas’ pipeline encompasses a range of validated and undruggable targets in oncology, immuno-oncology, and neuroscience. This includes three clinical-stage programs: bavdegalutamide (ARV-110) and ARV-766, which are being developed as potential treatments for men with late-line metastatic castrate-resistant prostate cancer, and ARV-471, which is being co-developed and commercialized by Arvinas and Pfizer as a potential treatment for patients with breast cancer.

#TeamArvinas is made up of more than 400 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and mission – to improve the lives of patients with serious diseases by pioneering therapies created with our revolutionary PROTAC® protein degradation platform. We’re really excited about the work we’re doing inside and outside of Arvinas, and think you will be, too. But don’t just take our word for it – learn more about life at Arvinas and what employees have to say. For more information, please visit www.arvinas.com.

 

Position Summary

The Senior Director, Quality Assurance is responsible for leading the teams responsible for quality assurance activities related to process and analytical development, manufacturing, testing, release, storage, shipment and/or distribution of active pharmaceutical ingredients (APls), API and drug product intermediates, and drug products undergoing development by the company. Under the direction of the Executive Director, Quality the position provides leadership and management support for the quality assurance team members engaged in the oversight of the various contract development and manufacturing organizations (CDMOs) and GMP-related service providers that perform process and analytical development, manufacturing, testing, and clinical supplies warehousing and distribution for the company.

The position is also responsible for participation in the development, maintenance, and execution of the Arvinas Quality System requirements as they pertain to the function, including supplier management, risk management, batch release, deviation and CAPA management, and change control, as well as the related continuous improvement initiatives. The incumbent works directly with the Arvinas Quality team and cross-functionally with Technical Operations; Regulatory CMC; Project and Asset Team Management; Clinical Operations; and the corresponding technical and quality assurance staff of the various CDMOs and GMP-related service providers to ensure effective execution of the Arvinas Quality System requirements and compliance with the applicable GxP regulations/ guidelines and industry standards.

This position reports to Executive Director, Quality and can be located at our headquarters in New Haven, CT or work remotely from a location within the U.S.

 

Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Leadership and direct 'hands on' support, when required, for the Quality Assurance (QA) teams providing QA oversight of suppliers (CDMOs and GMP-related service providers) contracted for the development, manufacturing, testing, shipment and/or distribution of Arvinas APls, API and drug product intermediates, and finished products. The scope of activities for these QA teams includes, but is not limited to:
    • Supplier audits to support approval of new suppliers; on-going qualification of existing suppliers; or to investigate specific events involving GMP compliance or product quality ('for cause' audits). Review and follow-up on audit responses from suppliers to ensure appropriate corrective and preventive actions (CAPA) are assigned and executed.
    • Review and approval of master batch records; product and material specifications; certificates of analysis; stability protocols and reports; validation protocols and reports; and other GMP-related documentation as developed I generated by the CDMOs and/or Arvinas Technical Operations.
    • Review of executed batch records, in-process test results, deviations, and laboratory records, including raw data, as required to accept or reject product (API, API intermediates, drug products) manufactured by the Issuance of batch releases or rejections on behalf of the company, as appropriate.
    • Review and/ or approval of deviations, CAPA, change requests and other related documentation as generated by suppliers, e.g., CDMOs or internal sources. Interfaces with the CDMOs and/or Arvinas Technical Operations to resolve any concerns, gaps, or discrepancies. Tracking of CMO deviations, CAPA and change requests per Arvinas Quality System requirements.
    • Development of Technical/ Quality Agreements with key suppliers.
    • Monitoring of supplier performance with respect to product quality, deviations, CAPA, audit results, regulatory inspections and reports on metrics related to supplier performance.
    • Review of CMC regulatory submissions for accuracy, technical content, and data integrity elements.
  • Participates as a key member of the project and asset teams to represent Quality Assurance and GxP regulatory requirements and ensure timely execution of responsibilities to meet the established project ti
  • Supports implementation, maintenance, and execution of Arvinas Quality Systems, including the development, review and/or approval of the associated policies, procedures, and work practices. Provides recommendations for improvements to existing quality system processes and procedures.
  • Participates as a member of the Arvinas Quality Board to report on supplier performance metrics/ KPls and GxP compliance risks and their management/mitigation.

 Qualifications

  • 15+ years of pharmaceutical quality assurance experience in support of product development, clinical and/or commercial manufacturing operations.
    • Strong hands-on knowledge of API and drug product (oral solids) manufacturing processes and the associated analytical test methods and specifications.
    • Experience with the application of phase-appropriate quality systems across the product development lifecycle (Phase 1 through commercial).
    • 5+ years of management experience in building, developing, and leading Quality Assurance teams for delivering effective quality assurance and compliance results for companies reliant on third-party manufacturing and testing services.
  • 5+ years of Pharmaceutical Quality Assurance experience in management/ oversight of contract operations, e.g., CDMOs, contract laboratories, clinical supply depots I distribution centers, including the conduct of qualification / GMP compliance audits.
  • Strong working knowledge in the application of the US and EU GMP regulations; ICH Guidance’s; and industry standard requirements for Pharmaceutical Quality
  • Experience in hosting regulatory inspections and in dealing with regulatory agencies throughout the drug product approval process.
  • Strong communication skills (verbal/ written).
    • Ability to effectively communicate with third party technical and quality assurance representatives to ensure Arvinas requirements are met and to resolve issues /
    • Ability to prepare standard operating procedures and deviation / CAPA reports in accordance with Arvinas Quality System requirements.
    • Oral and written presentation skills as needed to address colleagues at all levels of the organization, e.g., internal training presentations, presentation of COMO performance metrics, GxP risk management.
  • Ability to work on multiple projects, manage competing priorities, and collaborate cross­ functionally in a dynamic fast-paced environment.
  • Hands-on experience with the use of electronic document management and QMS systems; Veeva Quality Docs and Veeva QMS experience preferred.

Education

  • B.S. in Chemistry, Pharmacy, or a related scientific field. Advanced degree a plus, but not required.

 

#LI-Remote

 

Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit www.arvinas.com

Arvinas is an Equal Opportunity Employer   

Apply for this Job

* Required
resume chosen  
(File types: pdf, doc, docx, txt, rtf)
cover_letter chosen  
(File types: pdf, doc, docx, txt, rtf)
When autocomplete results are available use up and down arrows to review
+ Add another education


Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Arvinas’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.


Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.


Please reach out to our support team via our help center.