Arvinas is a clinical-stage biopharmaceutical company leading the way in targeted protein degradation therapeutics. Arvinas is the first company to focus solely on protein degradation and its platform technology is the most advanced in the field. Since its founding in 2013, Arvinas’ PROTAC® Discovery Engine has been driving the most significant breakthroughs in the industry. Arvinas’ pipeline encompasses a range of validated and undruggable targets in oncology, immuno-oncology, and neuroscience. This includes three clinical-stage programs: bavdegalutamide (ARV-110) and ARV-766, which are being developed as potential treatments for men with late-line metastatic castrate-resistant prostate cancer, and ARV-471, which is being developed as a potential treatment for patients with breast cancer.

#TeamArvinas is made up of more than 350 passionate and curious employees, whose diverse thoughts and perspectives are highly valued. Arvinas employees embrace the freedom to pursue innovation, think creatively, and give back. They are driven by the company’s values and purpose – to improve the well-being of patients and families impacted by the devastating diseases Arvinas is working to treat. It’s an exciting time to be in drug development and it’s an exciting time to be at Arvinas. But don’t just take our word for it – here’s what Arvinas employees are saying. For more information, please visit


Position Summary

Arvinas has an exciting opportunity for a Senior Medical Director, PV, who  will be responsible for global medical surveillance for the Arvinas marketed and/or investigational products assigned to him/her, including review and analysis of safety data from clinical trials and from post-marketing sources, providing medical expertise, the identification and investigation of safety signals, management of benefit-risk profile for assigned products and review and authoring of aggregate reports and safety sections of submission documents. S/he will be responsible for keeping upper management informed of safety issues. This is a critical role to ensure safety of patients taking Arvinas investigational and marketed products. 

This position reports to the Vice President of Pharmacovigilance and can be based in New Haven, CT, or can be performed in a hybrid or remote work arrangement. This position may require minimal travel.


Principal Responsibilities

Key responsibilities of this role include, but are not limited to:

  • Maintains expert knowledge of safety, including any emerging safety concerns and risk/benefit profile for responsible compounds, as well as regulatory guidelines as they pertain to drug safety/pharmacovigilance.
  • Responsible for Individual Case Safety Report (ICSR) review when applicable. Ensures completeness and accuracy of safety information in individual case reports through assessment of seriousness, expectedness, and causality, coding, review of narrative summary and providing case comments; provides medical inquiries for follow-up.
  • Attends cross functional and project specific team meetings to provide PV medical expertise.
  • Responsible for safety signal detection activities for assigned products and discusses safety signals as needed at the Safety Management team (SMT).
  • Responsible for contributing to and review of aggregate reports (DSUR, PSUR, RMP, ad-hoc safety reports) including but not limited to providing expert medical opinion. Drafts the appropriate safety sections as well as Risk/benefit sections for aggregate reports and applicable submission documents.
  • Provides medical opinion and safety input to inquiries from regulatory authorities, IRBs, ethics committees, etc.
  • Chairs the SMT and works effectively with all cross functional stakeholders (internal and external) to discuss and manage all new emerging safety signals from post-marketing and clinical trials environment.  
  • Exhibits good communication and fosters relationships with cross functional stakeholders on all pharmacovigilance related issues.
  • Responsible for the maintenance and updating of benefit-risk profile for assigned products through product lifecycle.
  • Contributes and reviews safety sections of study reports, protocols, informed consents, Company Core Data Sheets, Investigator Brochures, clinical summary of the NDA/MAA and product labeling.
  • Leads internal PV meetings (SMT, etc.) based on specific topics. 
  • Typically assigned work of a more complex nature and/or global products that are marketed with risk management programs.




  • Minimum of 6 years of experience in a Pharmacovigilance/Drug Safety environment with substantial experience in managing adverse event and SAE processing, medical surveillance and risk management, signal detection, on a global basis within the pharmaceutical industry.
  • Demonstrated leadership in medical surveillance issues and regulatory environment.
  • Knowledge of principles of epidemiology and statistics as relates to PV deliverables.
  • Experience with the use of global safety databases.
  • PV operational experience a plus
  • The candidate should have extensive knowledge of ICH/FDA guidelines for GCP and Clinical and post-marketing Safety Reporting.
  • Highly developed skills in verbal and written communication, planning, organization, with extensive knowledge of the investigational clinical study and post-marketing setting.
  • Expert understanding of the drug development process.
  • Ability to work in a highly organized team environment.
  • Demonstrated decision-making and problem solving skills coupled with a can-do attitude.
  • Ability to successfully lead and/or to manage and prioritize multiple critical issues simultaneously.
  • Attention to detail with a highly consistent focus on quality.
  • Ability to read, analyze, and interpret scientific and technical journals, financial reports, and legal documents.
  • Ability to respond to inquiries or complaints.
  • Ability to work with mathematical concepts such as probability and statistical measures.
  • Ability to apply concepts such as fractions, percentages, ratios, and proportions to practical situations.
  • Ability to define problems, collect data, establish facts, and draw valid conclusions.
  • Ability to interpret an extensive variety of technical information and deal with several abstract and concrete variables.
  • Experience with drug safety management tracking tools and electronic and safety databases.
  • Excellent PC skills including MS Office products (Word, Excel, and PowerPoint).



  • Medical degree (MD), or DO. 
  • An oncology board certification is a plus, but not required



Arvinas is proud to offer a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness and financial security of our employees and their families. Benefits include group medical, vision and dental coverage, group and supplemental life insurance, and much more. To learn more about Arvinas, please visit

Arvinas is an Equal Opportunity employer   

Apply for this Job

* Required
When autocomplete results are available use up and down arrows to review
+ Add Another Education

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Arvinas’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

1Section 503 of the Rehabilitation Act of 1973, as amended. For more information about this form or the equal employment obligations of Federal contractors, visit the U.S. Department of Labor's Office of Federal Contract Compliance Programs (OFCCP) website at

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.