About Arc Institute

The Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.

While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:

  • Funding: Arc will fully fund Core Investigator’s (PI’s) research groups, liberating scientists from the typical constraints of project-based external grants.
  • Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators. 
  • Support: Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.
  • Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.

Arc scaled to nearly 100 people in its first year. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly to several hundred in the coming years

About the position

We are looking for a Senior Research Associate to join the MultiOmics Tech Center at the Arc Institute. You will participate in projects utilizing the cutting-edge technologies of single cell assays as well as spatial genomics with close collaboration with other core labs and tech centers to understand the underlying mechanisms of complex diseases. The projects will focus on generating multiple genetic regulatory readouts (DNA, RNA, and protein) at individual cell level together with high content spatial information from organoids and tissues samples. The ideal candidate will have experience in next generation sequencing (NGS) and tissue processing as well as the motivation to learn and perform high throughput assays. This is an excellent opportunity for a highly motivated and curious researcher interested in the development of novel single cell high resolution assays in conjunction with the application of the modern CRISPR technology.

About You

  • You enjoy science and learning. Whether it’s gaining knowledge in new fields of scientific research or learning a new bench site technique, you are always curious and willing to step out of your comfort zone to acquire diverse experiences. 
  • You are detail oriented. You are careful and diligent about good documentation practices, good lab practices, and overall obsessed with keeping things organized. 
  • You love collaboration and value teamwork. Science is a team effort that you pride yourself in taking the initiative to participate and to offer help. 
  • You are a problem solver. Science isn’t perfect and it's common for you to come across issues you need to troubleshoot. You pride yourself in your ability to troubleshoot complex problems. 

Job Responsibilities

  • Perform daily activities related to sample preparations including cell culture, single cell/nuclei isolation and fixation, and tissue processing for spatial technology. 
  • Assist with single cell NGS experiments including library preparation from various platforms including but not limited to 10x 
  • Learn and assist with planning and execution of high throughput experiments and implementation of liquid handler automations.
  • Collaborate closely with scientists in the multiomics tech center to conduct potential functional readouts from CRISPR perturbation screening experiments.
  • Learn to conduct experimental planning, execution, analysis, troubleshooting and data interpretation with a high degree of independence and continued support from the rest of the team. 
  • Present results in tech center meeting and collaborators’ lab meetings

Job Requirements

  • BS + 4 years or MS + 2 years of equivalent professional experience in cellular biology, molecular biology, biochemistry, neuroscience, or another relevant field.
  • Hands-on industry experience using mammalian tissue cell culture, tissue processing/sectioning and/or single cell dissociation techniques.
  • Hands-on experience with NGS library prep and molecular cloning is highly desired.
  • Detail-oriented with excellent organizational and time management skills.
  • Outstanding critical thinking and problem-solving skills.
  • Strong oral and written communication skills.
  • Be both a strong individual contributor as well as a collaborative team member.

The base salary range for this position is $71,000 to $91,000. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.

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