About Arc Institute
The Arc Institute is a new scientific institution conducting curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.
While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:
- Funding: Arc will fully fund Core Investigators’ (PIs’) research groups, liberating scientists from the typical constraints of project-based external grants.
- Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.
- Support: Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.
- Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.
Arc scaled to nearly 100 people in its first year. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly to several hundred in the coming years.
About the position
We are looking for a Scientist to join our Genome Engineering Technology Center and support the development of cutting-edge functional genomics approaches focused on the high-throughput interrogation of mammalian genomes, transcriptomes and epigenomes with rich multi-omic readouts. You will work closely with other Scientists and Research Associates in Arc’s Technology Centers and Core Investigator labs with a mission to develop technology to understand and treat complex genetic disease. The ideal candidate will have a passion for technology development and a proven track record in developing high-throughput CRISPR screens in mammalian cell culture or animal models.
This is an excellent opportunity for a highly motivated and curious scientist interested in the intersection of basic research and biotech product development. Title and compensation will be competitive with industry jobs relative to experience level and background.
- You love science and the opportunities it creates. Functional Genomics is a new field filled with unanswered biological questions. You find excitement in the opportunity to address these questions with your functional genomics expertise.
- You are a collaborator. You’re an expert in your domain and you greatly enjoy working successfully with scientists from other teams, labs and scientific domains. You believe that working on projects with scientists from different backgrounds can lead to the most exciting and successful research.
- You build tools. As much as you love answering specific scientific questions, you also love creating technology and platforms that are scalable and useful in many different scientific application areas.
- You are an optimizer. In science, there’s always a race against the clock. You care deeply about making every step of the way as close to perfect as possible but also as quick and efficient as possible.
In this position you will
- Design and run pooled functional genomics screens to prototype new technology and generate key data sets for technology development
- Work closely with core academic labs on collaborative projects to execute pooled functional genomics screens and answer important scientific questions
- Provide technical input to the Genome Engineering Technology Center roadmap for functional genomics technology development
- Manage multiple projects, with responsibility for planning, tracking, and driving timely execution of research activities
- Report progress and present data in internal and external meetings
- PhD in molecular biology, bioengineering, genomics, cell biology or similar fields
- Demonstrated ability to implement pooled functional genomics screens with a record of academic publications or intellectual property
- Deep understanding of CRISPR editing systems and their application to pooled screens including gRNA design
- Hands-on experience with culturing and transfecting mammalian cell lines
- Ability to interpret pooled CRISPR screening data to answer key scientific questions and drive next steps in method development
- Experience working with and developing functional genomics screens in animal models is desirable but not required
- Experience developing pipelines for analyzing large-scale pooled screening data (eg. NGS) is desirable but not required
- Ability and desire to work in a fast-paced environment and be a team player
The base salary range for this position is $112,500 to $148,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, market conditions, education/training, skill level, and whether the compensation is internally equitable, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.