About Arc Institute

The Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.

While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:

  • Funding: Arc will fully fund Core Investigator’s (PI’s) research groups, liberating scientists from the typical constraints of project-based external grants.
  • Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators. 
  • Support: Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.
  • Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.

Arc scaled to nearly 100 people in its first year. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly to several hundred in the coming years.

 

About the position

We are looking for a passionate and outstanding scientist experienced in spatial-omics to join our Multi-omics technology center. In this role, you will lead our spatial biology research efforts, work closely with other talented scientists and bioinformaticians from the technology centers and the core investigator labs, evaluate, optimize, and develop new spatial genomics/multi-omics methods for studying neurodegenerative diseases and cancer.   The ideal candidate has a passion for developing new technologies and a proven track record in spatial technology publications or product development.  

This is an excellent opportunity for a highly motivated and curious scientist interested in the intersection of academic basic research and biotech assay/product development. Title and compensation will be competitive with industry jobs relative to experience level and background.  

Job Responsibilities

  • Lead research efforts in spatial genomics/multi-omics and contribute to the multi-omic center technology roadmap.
  • Work closely with core investigators and internal and external collaborators to gather user needs and define project scopes and priorities 
  • Evaluate commercial spatial omics systems, implement and optimize workflows and protocols for various sample types and applications
  • Develop novel molecular biology assays for spatial technologies including molecular barcoding, antibody conjugation, nucleic acid hybridization, amplification and sequencing techniques.
  • Troubleshoot and optimize molecular assays on custom systems
  • Drive technology development projects from concept through development and technology transfer
  • Managing multiple projects, have responsibility for planning, tracking, and driving timely execution of research activities
  • Report progress and present data in internal and external meetings 
  • Train junior scientists, RAs and graduate students

Job requirements

  • PhD in molecular biology, biochemistry, genomics, or similar fields
  • 5+ years’ relevant laboratory experiences in next-generation sequencing library preparation, cell culture, microscopy, PCR, or other nucleic acid or protein-based technologies.
  • Extensive experience in spatial genomics method or assay development, as demonstrated in peer-reviewed publications or conference presentations
  • Hands-on experience with tissue sample prep (fresh frozen, fixation,permeabilization, antibody staining, tissue clearing), hybridization probe design and optimization, and in situ sequencing assays
  • Knowledge and experience in fluorescence microscopy
  • Advanced experience in image analysis a plus
  • Neurobiology or cancer cell biology background a plus
  • Ability and desire to work in a fast-paced environment and be a team player

The base salary range for this position is $112,500 to $148,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, internal equity, market conditions, education/training, and skill level, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.

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