About Arc Institute

The Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.

While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:

  • Funding: Arc will fully fund Core Investigator’s (PI’s) research groups, liberating scientists from the typical constraints of project-based external grants.
  • Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators. 
  • Support: Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.
  • Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.

Arc scaled to nearly 100 people in its first year. With $650M+ in committed funding and a state of the art new lab facility in Palo Alto, Arc will continue to grow quickly to several hundred in the coming years.

 

About the position:

We are looking for a passionate and outstanding scientist with deep image-based screening technology development experience to join our Multi-Omic technology center. In this role, you will lead our efforts to evaluate, optimize, and develop image-based assays and workflows for high throughput genetic/epigenetic perturbations and screening.  You will work closely with other Arc tech centers and core investigators to combine cutting-edge gene editing, stem cel,l and single cell multiomics techniques in tackling neurodegenerative diseases and cancer.   The ideal candidate has a passion for developing new technologies and a stellar track record of publications or product development in image-based assays.  

This is an excellent opportunity for a highly motivated and curious scientist interested in the intersection of academic basic research and biotech assay/product development. Title and compensation will be competitive with industry jobs relative to experience level and background.  

Job Responsibilities

  • Lead technology development efforts in image-based phenotypic screening projects and contribute to the multi-omics tech center roadmap.
  • Work closely with core investigators and internal and external collaborators to gather user needs and define project scopes and priorities 
  • Work independently and collaboratively to develop and implement high throughput imaging systems and integrate morphology-based assays with genomic or functional readouts
  • Drive projects from concept through development and technology transfer
  • Managing multiple projects, have responsibility for planning, tracking, and driving timely execution of research activities
  • Report progress and present data in internal and external meetings 

Job requirements

  • PhD in bioengineering,  molecular and cell biology, genomics, or similar fields; or MS with >5 years of biotech industrial experience
  • Hands-on experiences in optical system set up, integration and automation 
  • Deep experience with various image analysis tools or hands-on coding experience in developing image analysis algorithms and pipelines
  • Deep expertise in image-based assay development and familiarity with fluorescence and confocal microscopy   
  • Neurobiology and cancer cell biology background a plus
  • Knowledge and experience of CRISPR screening,  Perturb-Seq or spatial genomics strongly desired
  • Experience with large data sets and machine learning a plus 
  • Strong self-drive and ability to work independently
  • Ability and desire to work in a fast-paced environment and be a team player

 

The base salary range for this position is $112,500 to $148,500. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, internal equity, market conditions, education/training, and skill level, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.

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