About Arc Institute
The Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.
While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:
- Funding: Arc will fully fund Core Investigator’s (PI’s) research groups, liberating scientists from the typical constraints of project-based external grants.
- Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators.
- Support: Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.
- Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.
With $650M in committed funding, the vision in the first 2-3 years is to grow to a team of roughly 150 team members, with plans for further significant growth over the decade ahead.
About the position
We are looking for an Associate Director to join our Genome Engineering Technology Center and lead the development of cutting-edge functional genomics approaches focused on the high-throughput interrogation of mammalian genomes, transcriptomes and epigenomes with rich multi-omic readouts. You will work closely with scientists and research associates in Arc’s Technology Centers and Core Investigator labs with a mission to develop technology to understand and treat complex genetic disease. The ideal candidate will have a passion for technology development and a proven track record in developing high-throughput CRISPR screens in mammalian cell culture or animal models.
This is an excellent opportunity for a highly motivated and curious scientist and project leader interested in the intersection of basic research and biotech product development. Title and compensation will be competitive with industry jobs relative to experience level and background.
- Aid in building and managing the functional genomics team through recruiting, mentoring and training a team of scientists and research associates
- Work with other scientific leaders at Arc to develop a technology roadmap for functional genomics innovation
- Work closely with core investigators and internal and external collaborators to gather needs and define project scopes and priorities
- Provide technical assistance and help troubleshoot functional genomics and pooled screens for technology center projects and across the organization
- Drive functional genomics technology development projects from concept through development and technology transfer
- Manage multiple projects, with responsibility for planning, tracking, and driving timely execution of research activities
- Report progress and present data in internal and external meetings
- PhD in molecular biology, bioengineering, genomics, cell biology or similar fields
- 8+ years of post-PhD experience in academia or the biotechnology industry
- 3+ years of previous managerial experience leading and growing scientific teams of 3+
- Demonstrated ability to develop novel functional genomics screens with a record of academic publications or intellectual property
- Deep understanding of CRISPR editing systems and their application to pooled screens
- Hands-on experience with culturing various mammalian cell types including cancer cell lines, stem cells and primary cells
- Experience working with and developing functional genomics screens in animal models is desirable but not required
- Ability to design editing reagents for high-throughput pooled screens and analyze large, complex data sets using tools such as Python and R
- Ability and desire to work in a fast-paced environment and be a team player
The base salary range for this position is $147,000 to $171,000. These amounts reflect the range of base salary that the Institute reasonably would expect to pay a new hire or internal candidate for this position. The actual base compensation paid to any individual for this position may vary depending on factors such as experience, internal equity, market conditions, education/training, and skill level, and does not include bonuses, commissions, differential pay, other forms of compensation, or benefits. This position is also eligible to receive an annual discretionary bonus, with the amount dependent on individual and institute performance factors.