About Arc Institute

The Arc Institute is a new scientific institution that conducts curiosity-driven basic science and technology development to understand and treat complex human diseases. Headquartered in Palo Alto, California, Arc is an independent research organization founded on the belief that many important research programs will be enabled by new institutional models. Arc operates in partnership with Stanford University, UCSF, and UC Berkeley.

While the prevailing university research model has yielded many tremendous successes, we believe in the importance of institutional experimentation as a way to make progress. These include:

  • Funding: Arc will fully fund Core Investigator’s (PI’s) research groups, liberating scientists from the typical constraints of project-based external grants.
  • Technology: Biomedical research has become increasingly dependent on complex tooling. Arc Technology Centers develop, optimize and deploy rapidly advancing experimental and computational technologies in collaboration with Core Investigators. 
  • Support: Arc aims to provide first-class support—operationally, financially and scientifically—that will enable scientists to pursue long-term high risk, high reward research that can meaningfully advance progress in disease cures, including neurodegeneration, cancer, and immune dysfunction.
  • Culture: We believe that culture matters enormously in science and that excellence is difficult to sustain. We aim to create a culture that is focused on scientific curiosity, a deep commitment to truth, broad ambition, and selfless collaboration.

With $650M in committed funding, the vision in the first 2-3 years is to grow to a team of roughly 150 team members, with plans for further significant growth over the decade ahead. 

About the position
The Gilbert lab at the Arc Institute, and the University of California, San Francisco is seeking applications for a research technician. The position will include significant portion of research as well as support of existing research projects in the Gilbert lab.

The Gilbert labs expertise is in synthetic biology, functional genomics and cancer biology. We are building new CRISPR tools to edit the epigenome and manipulate gene expression in a multiplexable and tunable manner. We are developing functional genomics tools to scalably manipulate expression of pairs and sets of genes to map how genes work together to modulate complex phenotypes.

We also use genome scale screens, single cell functional genomics and genetic interaction mapping to model and map the genetic and epigenetic causes underlying aggressive cancer phenotypes such as metastasis and drug resistance.

In this position you will:
● Work as part of a fully funded team to conduct experiments involving high-throughput functional genomics in human cells, molecular and cellular assays, and models of disease.
● Collaborate closely with the PI and Gilbert lab members on planning and executing scientific research projects. The successful candidate will enable existing projects and in due course lead an independent research project under supervision.
● Develop standardized protocols for the lab, assist with lab management and provide training to lab personnel as needed under supervision of the PI or senior lab members.

Requirements
● Candidates must have a bachelor’s degree in a relevant life sciences or engineering field as well as significant relevant research experience.
● The following specific areas of expertise would be considered an asset for this role: mammalian cell culture, molecular biology, CRISPR genome engineering, functional genomics, and programming in python or R
● Outstanding written and verbal communication skills is required
● Enthusiasm for enabling existing projects within the lab
● The successful candidate will be an ambitious self-starter, be motivated to apply their skills to diverse projects and enjoy working in a collaborative and fast-paced team environment

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