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Principal Scientist, Biomarker Discovery & Development

Remote

 

About Apogee Therapeutics
Founded in 2022, Apogee Therapeutics, Inc. (Ticker: APGE) is a well-funded, Nasdaq listed company that offers the opportunity to work in a fast-paced, highly dynamic environment. At Apogee, you can actively contribute to shaping the company culture, take on various roles and responsibilities, and grow professionally.
Apogee Therapeutics, Inc. is a biotechnology company seeking to develop differentiated biologics for the treatment of atopic dermatitis, chronic obstructive pulmonary disease and other inflammatory and immunology indications with high unmet need. Our antibody programs are designed to potentially overcome limitations of existing therapies by targeting well-established mechanisms of action and incorporating advanced antibody engineering to optimize half-life and other properties. We seek to reshape the current standard of care for inflammatory and immune diseases because we believe people living with these diseases deserve the best possible treatment, and we refuse to stop at “good enough.”
We are a fast-paced company committed to building an exceptional company culture, founded on our C.O.R.E. values: Caring, Original, Resilient and Egoless. 
If this sounds like you, keep reading!

 

Role Summary

The Research and Translational Medicine (RTM) department is seeking a Principal Scientist, Biomarker Discovery and Development. This newly created role will be responsible for the execution of biomarker strategies to support clinical programs in I & I indications, such as asthma, COPD, atopic dermatitis, and EOE. Reporting to the Associate Director of Biomarker Discovery & Development, you will collaborate cross-functionally with research, translational medicine, and clinical teams to advance biomarker-driven decision-making.

Key Responsibilities

  • Collaborate with internal teams and external partners (CROs) to support the execution of biomarker strategies for clinical programs 
  • Manage day-to-day operations of biomarker strategies for clinical programs, including resourcing and oversight of assay selection, feasibility, troubleshooting, qualification, and clinical sample testing, jointly with the RTM Operations Team
  • Analyze and interpret biomarker data, integrating findings with clinical and translational research insights
  • Support the design and management of biomarker discovery studies, including but not limited to academic collaborations and ex vivo experiments
  • Support the review of clinical study-related documents, including study protocol, lab manual, analysis plan, as well as publications related to biomarker findings
  • Stay current with emerging biomarker technologies, regulatory guidelines, and industry best practices to refine biomarker approaches

Ideal Candidate

  • PhD with 5 plus years, or MS with 8 plus years of pharmaceutical/biotech industry experience
  • Experience in biomarker discovery, validation, and clinical implementation
  • Experience in I&I indications in Respiratory such as asthma and COPD preferred 
  • Hands-on experience with omics technologies (e.g., NGS, proteomics) and biomarker assay development (e.g., flow cytometry, immunoassays, mass spectrometry)
  • Proficiency in data analysis tools (e.g., R, Python) to support biomarker discovery and development efforts preferred
  • Good understanding of drug development stages and how to design biomarker strategies to support clinical development  
  • Experience working on cross-functional teams within a biotech/pharmaceutical environment
  • Excellent communication, project management, and leadership skills
  • Enjoys fast paced environment, flexible, able to manage multiple and competing priorities under tight timelines
  • Successfully exhibit Apogee’s C.O.R.E. values: Caring, Original, Resilient and Egoless
  • Position requires 10 – 15% travel for regular team meetings including All Hands meetings and other workshops

The anticipated salary range for candidates for this role will be $170,000-$195,000 / year. The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography. 

 

What We Offer
  • A great culture, grounded in our C.O.R.E. values: Caring, Original, Resilient and Egoless
  • Opportunity to work in a fast-paced, highly dynamic environment where you help shape the culture and company, wear multiple hats, and learn quickly
  • Market competitive compensation and benefits package, including base salary, performance bonus, equity grant opportunities, health, welfare & retirement benefits
  • Flexible PTO
  • Two, one-week company-wide shutdowns each year
  • Commitment to growing you professionally and providing access to resources to further your development
  • Apogee offers regular all team, in-person meetings to build relationships and problem solve
 
E-Verify Participation: As part of the I9 verification of authorization to work in the US, Apogee participates in E-Verify. To learn more about E-Verify please review this poster.
 
Apogee Therapeutics is proud to be an Equal Opportunity employer. All qualified applicants will receive consideration for employment without regard to sex, gender identity, sexual orientation, race, color, religion, national origin, disability, protected Veteran status, age, or any other characteristic protected by law.
 
To review our privacy policy, click here

 

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