What Is Alterome?

Alterome Therapeutics is a privately held, precision oncology biotechnology company developing a portfolio of alteration-specific therapeutics to address high-value and validated oncogenic drivers.  Alterome was founded in December 2021 with a $64M Series A from OrbiMed, Vida Ventures, Nextech Invest, and Boxer Capital.  The company raised an additional $35M that closed in November 2022 adding Colt Ventures to the syndicate, bringing the total funds raised to nearly $100M. The company is led by an expert team of precision oncology R&D leaders with a history of developing marketed oncology small molecule drugs. 

Our vision unites us; we relentlessly push the boundaries of cancer treatments to transform the lives of patients, one alteration at a time.  Thus, we seek the best people to join our special movement and invest the resources they need to grow, develop, and accomplish our collective goals.

Alterome is located in San Diego, CA.

Who Are Alterome Employees?

Although we share varied backgrounds and come with expertise in different areas, we aim to inspire hope for those affected by cancer. We have a passion for what we do and truly enjoy working with each other. In fact, many of us have worked together in multiple companies and there is a genuine camaraderie among the group. We would love to bring new faces to the team, and that’s where you come in! Alterome Employees are creating a Movement. We are open-minded individuals who “get it done” individually to accomplish our collective mission…together, we will elevate the standards for the next generation of targeted therapies.

Our people make the difference! If you share our vision to transform the lives of cancer patients, join our Movement.

Alterome is currently seeking…

An exceptional Computational Chemist to develop and apply state of the art methodologies to the discovery of new cancer therapeutics.  Scientific level is open and will be commensurate with experience and track record. As the successful candidate, you will interact closely with a passionate, focused, and experienced group of industry leaders united in our single-minded vision and determination to defeat cancer, one alteration at a time.  The ability to collaborate proactively and productively with experimental scientists across chemistry, biology, and biophysics in a team environment is a must.

How You’ll Contribute to the Team…

  • Application of theoretical and computational chemistry techniques as implemented in current commercial, academic, and/or internal software packages to the discovery and optimization of new therapeutic candidates
  • Development and application of new computational methodologies to small molecule lead discovery and optimization
  • Collaboration with and oversight of external partners involved in biological, structural, biophysical, PKDM, or other assay work
  • Close collaboration with cancer biology and genomics experts in the discovery and assessment of potential new targets / pathways suitable for small molecule intervention
  • Education and training of experimental chemical and biological scientists within Alterome in the use of above methodologies and resources
  • Proactive contribution to patent applications and scientific publications

What You Bring with You…

  • Ph.D. degree in Chemistry, Chemical Physics, or related field
  • Mastery of one or more of the standard computational chemistry / life sciences modeling program suites (Schrödinger, MOE, others)
  • High proficiency with one or more molecular dynamics software suites (AMBER, Desmond, GROMACS, NAMD, others)
  • Experience with the application of machine learning / AI methodology to either lead optimization or algorithmic development
  • Awareness of the current state of the literature with regard to computational approaches, applied or potentially adaptable to the discovery of new medicines
  • Proficiency with Linux at the command line level
  • Programming / scripting capability (Python / bash highly desirable)
  • Demonstrated interaction with structural biology (e.g. X-ray crystallography / Cryo-EM) and biophysics personnel with a strong working understanding of such approaches
  • Ability to operate with a high degree of professionalism, flexibility, self-motivation and adaptiveness to change in a fast-moving start-up environment
  • Strong collaborative, coaching, and teaching skills


Additional Preferred or Highly Desirable Qualifications:

  • 4+ years of direct experience in the drug discovery environment, either in a large biopharma or startup setting
  • Deep subject matter expertise in one or more of the following disciplines: relative binding free energy (RBFE) determination via thermodynamic integration (TI) and free energy perturbation (FEP) approaches at large scale, quantum chemistry, QM/MM and/or linear-scaling QM methods (e.g. FMO or related approaches) with demonstrated application of any of the above to one or more drug discovery campaigns
  • A track record indicating clear, unequivocal impact to one or more drug discovery programs, with demonstration of one or more instances where the application of computational methods was pivotal to the advancement of the program

Salary Range: 170,000 - $190,000 annually (plus equity) depending upon experience

What Alterome Brings…

We provide our employees medical/dental/vision/life insurance, 401k w/match, competitive comp (including equity), paid holidays, flexible time off, home office set up, full-service gym on-site (with showers and towel service!), development opportunities, phenomenal company culture, and more!

EEOC Statement…

Alterome Therapeutics, Inc. is an equal-opportunity employer committed to building a diverse and inclusive organization. We measure each applicant, candidate, and employee based on their qualifications for the role, regardless of age, sex, religion, sexual orientation, gender identity, national origin, Veteran status, disability, and/or any other protected class characteristics. Furthermore, Alterome is committed to achieving all business objectives in compliance with all federal, state, and local laws.

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