Who we are

Alltrna is the world’s first tRNA platform company to decipher tRNA biology and pioneer tRNA therapeutics to treat thousands of diseases. Alltrna unlocks tRNA biology to correct disease. The company's platform incorporates AI/ML tools to learn the tRNA language and deliver diverse programmable molecules with broad therapeutic potential. Alltrna has an unprecedented opportunity to advance a single tRNA medicine to unify treatment across a wide range of diseases with the same underlying genetic mutation. Alltrna was founded in 2018 by Flagship Pioneering. For more info, visit www.alltrna.com.

Flagship Pioneering has conceived of and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Editas Medicine (NASDAQ: EDIT), Omega Therapeutics (NASDAQ: OMGA), Seres Therapeutics (NASDAQ: MCRB), and Indigo Agriculture. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures. In 2021, Flagship Pioneering was ranked 12th globally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.

Position Summary

We are looking for an experienced builder and service-oriented leader to drive the development and innovation across Alltrna’s Informatics, Information Technology, and Cyber Security disciplines. This function encompasses all aspects of foundational digital infrastructure and systems that enable and support work across Alltrna: IT, Informatics, Security, and Software and Data Engineering. You will lead and operate at all levels, managing a growing digital team and diverse vendor landscape, drive and execute multi-disciplinary digitals products and services, and manage stakeholders and leaders across the organization.

Key Responsibilities

  • Partner with stakeholders across the organization to understand business needs – Discovery Platform, Development, Medicinal Chemistry, G&A, CMC, Regulatory and Medical Affairs and more.
  • Develop and own the vision and roadmap for Digital Systems aligned with corporate objectives.
  • Identify objectives, priorities, risks, and metrics to measure impact; align scope with leadership team.
  • Drive the design, development, deployment, adoption, and ongoing operation of stage-appropriate integrated digital systems to support and enable the work of end users in functions across the company.
  • Communicate plans and progress to other senior leaders, the Executive leadership team, and Board of Directors.
  • Advocate for and drive best practices and standards in technical and operational capabilities.
  • Grow, lead, and develop a team of engineers, and IT professionals.
  • Enable and lead a culture of continuous innovation, including best practices in project management and software/automation development.
  • Develop and manage progress against hiring plans, budgets, and goals.

Basic Qualifications

  • Bachelor or technical degree with evidence of advanced technical or management training. (e.g. PhD, MS, MBA, Certified AWS Solution Architect).
  • 15+ years of technical experience in Digital positions, ideally in a biotech or startup environments.
  • Progressively increasing levels of leadership responsibility, including building teams and developing individuals.
  • Deep technical understanding in multiple areas of IT, informatics, software engineering, data engineering, and cybersecurity (including as an individual contributor in some of these areas).
  • Demonstrated ability to deliver complex, multi-disciplinary digital projects to production use and impact on the organization.
  • Excellent written and oral communication skills.
  • Experience working in a regulated environment.

Preferred Qualifications

  • Experience in organizational or team start-up, demonstrating a high degree of ownership and hands-on building digital products, IT services and teams.
  • Demonstrated delivery of advanced clinical informatics solutions through implementation of standards and technology, including healthcare (HL7 FHIR), observational research (OMOP), and interventional research (SDTM), as well as diverse data type integration (e.g., omics, manufacturing, claims).

Personal Characteristics

  • Agility: Ability to work in a high energy organization with evolving goals and deliverables
  • Results Oriented: Self-motivated, curious, accomplishes goals with minimal oversight
  • Communication: Outstanding written and verbal communication skills, ability to work well with colleagues from diverse backgrounds and cultures
  • Authenticity: Ability to voice their opinion and provide insight to the broader team, even when holding a minority or “out of the box” opinion. Ability to thrive with input from a cross-functional team while remaining the unquestioned scientific expert
  • Team player: Desire to routinely interact with and mentor team members

What We’ll Offer You

  • Comprehensive, competitive healthcare and dental coverage through Blue Cross Blue Shield, vision coverage through VSP, family leave, paid time off, 401k retirement plan, disability and life insurance, and fully covered parking/commuter benefits.
  • A dynamic early-stage work environment and highly interdisciplinary, talented, and collaborative team.
  • Participation in an unprecedented opportunity to advance a single tRNA medicine to restore disrupted protein production, regardless of target, for thousands of diseases with the same underlying genetic mutation.
  • Professional growth opportunities through mentoring, training, immersion in cross-functional projects, and opportunities to learn and try new things.

 Our Core Values

  1. PATIENTS DESERVE BETTER. We are transforming medicine, boldly building a new future for patients.
  2. CURIOSITY SPARKS DISCOVERY. We ardently explore the unknown, catalyzing new scientific breakthroughs.
  3. COURAGE PROPELS US FORWARD. We take thoughtful risks without fear of failure, growing with each experience.
  4. OUR PURPOSE FUELS US. We each lead and work with focus and passion to design groundbreaking tRNA medicines.
  5. WE ARE ONE TEAM. We are united on trust and collaboration, embracing all voices and experiences.


Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

Apply for this Job

* Required
resume chosen  
(File types: pdf, doc, docx, txt, rtf)
cover_letter chosen  
(File types: pdf, doc, docx, txt, rtf)
+ Add another employment

Please reach out to our support team via our help center.