About Alltrna

Flagship Pioneering has conceived of and created companies such as Moderna Therapeutics (NASDAQ: MRNA), Editas Medicine (NASDAQ: EDIT), Omega Therapeutics (NASDAQ: OMGA), Seres Therapeutics (NASDAQ: MCRB), and Indigo Agriculture. Since its launch in 2000, Flagship has applied its unique hypothesis-driven innovation process to originate and foster more than 100 scientific ventures. In 2021, Flagship Pioneering was ranked 12th globally on Fortune’s “Change the World” list, an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies.

Alltrna is the world’s first tRNA platform company to decipher tRNA biology and pioneer tRNA therapeutics to treat thousands of diseases. Alltrna unlocks tRNA biology to correct disease. The company's platform incorporates AI/ML tools to learn the tRNA language and deliver diverse programmable molecules with broad therapeutic potential. Alltrna has an unprecedented opportunity to advance a single tRNA medicine to unify treatment across a wide range of diseases with the same underlying genetic mutation. Alltrna was founded in 2018 by Flagship Pioneering. For more info, visit www.alltrna.com.

About The Role 

Come join a creative and collaborative team of scientists dedicated to leveraging emerging insights in RNA biology. We develop novel classes of oligonucleotide therapeutics to treat human diseases and improve human health. You will play a critical/vital role in DMPK Group and work closely with internal partners and external collaborators to enable the identification of multiple drug candidates for human clinical studies. Please apply if you feel that you can contribute to growing our team and advancing our mission.

We are seeking a collaborative and highly motivated DMPK Scientist. To succeed, you will need to be an enthusiastic team player, detail-oriented, organized, and comfortable working on complex problems. The work will involve the design, placement, monitoring, data analysis, and reporting of the in vivo and in vitro studies to support the development of tRNA-based therapies. You are expected to work in the dynamic environment interacting with multiple upstream and downstream functions.

Core Responsibilities 

  • Design, implement and interpret the results of in vivo and in vitro DMPK studies.
  • Oversee external studies at CROs and serve as a point contact for Alltrna.
  • Perform analysis, QC, and reporting of PK data.
  • Maintain comprehensive documentation of DMPK studies, relevant communications and data.
  • Prepare research reports and contribute to the preparation of regulatory applications.
  • Serve as DMPK and bioanalytical representative on cross-functional project teams.

Qualifications and Skills

  • PhD in biology, pharmacology, or related field of study with minimum of 5 years in the biotech or pharmaceutical industry working on multifunctional project team.
  • Expert comprehensive knowledge of DMPK assessments of preclinical drug candidates in general, and preferably oligonucleotides.
  • Working knowledge of documents preparation for regulatory submissions.
  • Deep understanding of the drug discovery process, from target validation through identification of drug candidates for clinical development.
  • Expertise in design and analysis of in vivo pharmaco- and toxicokinetic study designs and analyses.
  • General knowledge of bioanalytical techniques relevant to nucleic acids quantification.
  • Demonstrated ability to represent DMPK function in matrixed environments.
  • Expert knowledge in data spreadsheets (Excel), GraphPad Prism and WinNonlin  to process and present the DMPK data in support internal reports and regulatory submissions.

      The preferred candidate will ideally also possess the following skills and knowledge:

  • Knowledge of specialty software for PK/PD analysis and modeling (WinNonlin, Berkley Madonna, R).

What We’ll Offer You

  • Comprehensive, competitive healthcare and dental coverage through Blue Cross Blue Shield, vision coverage through VSP, family leave, paid time off, 401k retirement plan, disability and life insurance, and fully covered parking/commuter benefits.
  • A dynamic early-stage work environment and highly interdisciplinary, talented, and collaborative team.
  • Participation in an unprecedented opportunity to advance a single tRNA medicine to restore disrupted protein production, regardless of target, for thousands of diseases with the same underlying genetic mutation.
  • Professional growth opportunities through mentoring, training, immersion in cross-functional projects, and opportunities to learn and try new things.

Our Core Values

  1. Fast-acting/efficient. Moves quickly and proactively with a strong work ethic to produce high-quality results while fostering a positive work environment. Focuses on key priorities. Demonstrates tenacity and willingness to go the distance to get something done.
  2. Integrity. Does not cut corners ethically. Earns trust and maintains confidences. Does what is right not just what is politically expedient. Speaks plainly and truthfully. Follows-through on commitments. Expects a high level of personal performance and team performance.
  3. Critical thinking. Learns quickly. Demonstrates ability to proficiently understand new information and independently achieve meaningful outcomes. Able to structure and process qualitative/quantitative data and draw insightful conclusions.
  4. Creativity & Innovation. Scientifically curious and bold. Generates new and creative approaches to problem solving. Positive ‘can-do’ attitude. Views the toughest challenges as the greatest opportunities for personal growth and company innovation. Able to challenge dogma.
  5. Teamwork. Fully engaged in facilitating personal and team success. Reaches out to peers and cooperates with the team to establish an overall collaborative work environment. Often solicits and responds well to constructive feedback. Possesses good written and oral communication skills with the ability to clearly and concisely convey ideas and opinions.
  6. Flexibility/adaptability. Adjusts quickly to changing strategic and tactical priorities. Comfortable with ambiguity. Self-starter mentality.
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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