Alltrna is the world’s first tRNA platform company to decipher tRNA biology and pioneer tRNA therapeutics to treat thousands of diseases. Alltrna unlocks tRNA biology to correct disease. The company's platform incorporates AI/ML tools to learn the tRNA language and deliver diverse programmable molecules with broad therapeutic potential. Alltrna has an unprecedented opportunity to advance a single tRNA medicine to unify treatment across a wide range of diseases with the same underlying genetic mutation. Alltrna was founded in 2018 by Flagship Pioneering. For more info, visit www.alltrna.com.
About The Role
Come join a creative and collaborative team of scientists dedicated to leveraging emerging insights in RNA biology to develop novel classes of oligonucleotide therapeutics to treat human diseases and improve human health. In this role you will play a critical role in the company’s efforts to progress tRNA candidates to IND and early clinical studies. You will serve as a subject area expert and will contribute deep scientific know-how and expertise in immunology and will develop, formulate and explore hypotheses and interpret results from in vitro and in vivo pre-clinical data in collaboration with program teams. Please apply if you feel that you can contribute to growing our team and advance our mission. As an early member of a privately held, well-funded, early-stage platform biotechnology company, you will contribute to the platform development, drug discovery, and translation into the clinic along with opportunities for professional growth. You will also benefit from opportunities to engage with the broader Flagship Pioneering ecosystem.
We are seeking a talented and highly motivated scientist to lead and support a variety of preclinical activities including characterization of immune response to nucleic acid therapeutic in broad range of indications. In this role, you will deliver innovative and robust assay solutions and contribute to multiple projects and activities in a nimble working environment. This position will interact with Cell & Organismal Biology, Pharmacology, Discovery and other functions across the organization as well as external partners (e.g., CROs or and academic organizations laboratories). As a senior member of the team, you will have the opportunity to serve as a project team leader or provide key technical knowledge to a project teams.
- Contribute deep scientific know-how and work across program teams to provide immunology expertise and design experiments to characterize immune response to nucleic acid therapeutic and decipher the interplay of RNA-formulation with immune cells and complement
- Be responsible for the planning, development, and execution of cellular/immunology cell-based assays to assess immunogenicity and investigate mechanism of innate immune activation in vitro and in vivo
- Design, develop and validate ligand binding assays (ELISA, MSD or multiplexed bead arrays) to quantify cytokines/chemokines in various matrixes in vitro and ex vivo
- Design, perform and analyze well controlled in vivo and in vitro experiments to develop a rich mechanistic understanding of immune activation and immune cell trafficking to tissues or tumor microenvironment
- In this role you may also contribute to the execution of a research strategy focused on the evaluation of novel combination approaches for a broad range of indications including cancer therapy
- Ensure appropriate data analysis and interpretation to support decision making
- Responsible for effective project management and utilization of internal and external (i.e., CRO) resources
- Mentor, motivate and develop junior scientists and research associates
Qualifications and Skills
- PhD in immunology, cell biology, pharmacology, or related field of study with minimum of 3 years in the biotech or pharmaceutical industry working in multifunctional project teams
- Deep understanding of drug discovery process, with a track record of defining key experiments and developing robust and relevant in vitro model across several therapeutic areas to rapidly drive programs to go/no go decision points
- Demonstrate in-depth expertise in immunology and cellular pharmacology with extensive hands-on experience designing, troubleshooting, and implementing cellular/immunology cell-based assays to assess immunogenicity and investigate the mechanism of innate immune activation in vitro and in vivo
- Experience in independently planning, developing, and executing ligand binding assays (ELISA, MSD or multiplexed bead arrays) to quantify cytokines/chemokines in various matrixes in vitro and ex vivo
- Strong data processing and analysis skills covering single point and dose response analyses; ability to share assay data with project teams and research leadership
- Proficient in isolating primary mouse and human immune cell subsets for utilization in immunological assays; advanced knowledge of high-dimensional flow cytometry and FACS-based immunophenotyping (both panel design and downstream data analysis using FlowJo, Cytobank, or similar software).
- Excellent organizational skills, attention to accuracy and detail, and the ability to handle multiple projects in parallel
- Excellent communication and presentation skills, capable of conveying scientific information in a concise and effective manner
- Excellent cross-functional collaboration, and interpersonal skills
- Prior experience training, supervising and mentoring RAs
The preferred candidate will also possess the following skills
- Broad disease related experience with firsthand knowledge in oligo-based molecules
- Previous experience with a broad range of indications including in liver diseases, oncology, IO etc.
- In vivo mouse studies experience (live handling, post-mortem tissue acquisition and processing) or the willingness to learn