About Alltrna

Alltrna is the world’s first tRNA platform company to decipher tRNA biology and pioneer tRNA therapeutics to treat thousands of diseases. Alltrna unlocks tRNA biology to correct disease. The company's platform incorporates AI/ML tools to learn the tRNA language and deliver diverse programmable molecules with broad therapeutic potential. Alltrna has an unprecedented opportunity to advance a single tRNA medicine to unify treatment across a wide range of diseases with the same underlying genetic mutation. Alltrna was founded in 2018 by Flagship Pioneering. For more information please visit www.alltrna.com.

About The Role 

Alltrna is seeking a highly motivated and talented Senior Scientist to join our Cell & Organismal Biology team. The successful candidate will be a key driver in expanding Alltrna’s disease modeling platform, and use state-of-the-art technologies to engineer, differentiate and utilize clonal CRISPR/Cas9-edited hPSC lines to enhance the throughput and physiological relevance of disease models. This role provides a unique opportunity to apply human pluripotent stem cell research to support drug discovery and therapeutic development.  The candidate will have a proven track-record of scientific excellence as evidenced by a strong publication and/or patent record. She/he will work with multifunctional groups to make research strategies, design, and perform experiments to evaluate new technologies while supervising and training junior team members. He/she should be a strong team player, clear communicator, enjoy scientific discovery and work effectively in a collaborative interdisciplinary environment.

Core Responsibilities:

  • Establish efficient and robust protocols to generate various specific cell types (hepatocytes, neuron, RPE, or muscle) from human pluripotent cells to model human diseases
  • Develop disease phenotype-specific molecular and functional assays such as enzymatic activity, receptor function, metabolic assays in relevant cell types differentiated from human pluripotent stem cells
  • Introduce disease-causing mutations using CRISPR/Cas9 technology or other related gene-editing platforms
  • Design and execute experiments, interpret experimental data, establish workflows including standard cell biology and stem cell biology methods
  • Design and execute preclinical in vitro and ex vivo experiment to support both mechanism of action studies and the clinical translation for engineered tRNA therapeutic development
  • Continually cultivate scientific/technical expertise through critical review of the scientific literature, attending external conferences, and developing relationships with key opinion leaders

Qualifications and Skills:

  • PhD in cell & molecular biology, chemical biology, or a related discipline with 6+ years of experience (for Sr. Scientist) in biotech or pharmaceutical company
  • Proven expertise in developing novel human stem cell approaches, applications to unique biological problems, profiling, and assay development
  • Deep knowledge of human pluripotent stem cell culture, characterization, QC, and differentiation (hepatocytes, neuron, RPE, or muscle)
  • Strong background and hands-on experience in hepatic biology
  • Proven hands-on experience with a variety cell-based and molecular biology techniques, such as FACS, flow cytometry, RT-qPCR, ELISA, immunostaining, high-content and confocal imaging, genetic and epigenetic assessment
  • Extensive experience with gene editing applications, e.g., gene knock-out, targeted knock-in, multiplexed gene editing, and base editing)
  • Experience in technique for genetic manipulation using siRNA, lentivirus, or PiggyBac system
  • Demonstrated ability to work in a dynamic environment as a team player with a strong work ethic, excellent communication, and time management skills
  • Foster a collaborative, creative, and rigorous culture of scientific discovery

Preferred Skills:

  • Experience with microphysiological systems including 3D multi-cellular culture models, organoids, bioprinting, organ-on-a-chip models
  • Experience designing AAV expression vectors, gene delivery in vitro and in vivo is a plus.

What We’ll Offer You:

  • Comprehensive, competitive healthcare and dental coverage through Blue Cross Blue Shield, vision coverage through VSP, family leave, paid time off, 401k retirement plan, disability and life insurance, and fully covered parking/commuter benefits.
  • A dynamic early-stage work environment and highly interdisciplinary, talented, and collaborative team.
  • Participation in an unprecedented opportunity to advance a single tRNA medicine to restore disrupted protein production, regardless of target, for thousands of diseases with the same underlying genetic mutation.
  • Professional growth opportunities through mentoring, training, immersion in cross-functional projects, and opportunities to learn and try new things.
  • Get to be part of the team that writes the analytical playbook for developing tRNA molecules and you will be critical not only in ensuring that we can understand the impurity profiles of our tRNA molecules but also in defining how we build control strategies with chemists and engineers to drive manufacturing for our clinical programs.
  • Daily on-site snacks, cold brew coffee, and Bevi, as well as weekly catered lunches.

Our Core Values

  1. Fast-acting/efficient. Moves quickly and proactively with a strong work ethic to produce high-quality results while fostering a positive work environment. Focuses on key priorities. Demonstrates tenacity and willingness to go the distance to get something done.
  2. Integrity. Does not cut corners ethically. Earns trust and maintains confidences. Does what is right not just what is politically expedient. Speaks plainly and truthfully. Follows-through on commitments. Expects a high level of personal performance and team performance.
  3. Critical thinking. Learns quickly. Demonstrates ability to proficiently understand new information and independently achieve meaningful outcomes. Able to structure and process qualitative/quantitative data and draw insightful conclusions.
  4. Creativity & Innovation. Scientifically curious and bold. Generates new and creative approaches to problem solving. Positive ‘can-do’ attitude. Views the toughest challenges as the greatest opportunities for personal growth and company innovation. Able to challenge dogma.
  5. Teamwork. Fully engaged in facilitating personal and team success. Reaches out to peers and cooperates with the team to establish an overall collaborative work environment. Often solicits and responds well to constructive feedback. Possesses good written and oral communication skills with the ability to clearly and concisely convey ideas and opinions.
  6. Flexibility/adaptability. Adjusts quickly to changing strategic and tactical priorities. Comfortable with ambiguity. Self-starter mentality.
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

Apply for this Job

* Required
+ Add Another Employment