About Alltrna

Alltrna is the world’s first tRNA platform company to decipher tRNA biology and pioneer tRNA therapeutics to treat thousands of diseases. Alltrna unlocks tRNA biology to correct disease. The company's platform incorporates AI/ML tools to learn the tRNA language and deliver diverse programmable molecules with broad therapeutic potential. Alltrna has an unprecedented opportunity to advance a single tRNA medicine to unify treatment across a wide range of diseases with the same underlying genetic mutation. Alltrna was founded in 2018 by Flagship Pioneering. For more info, visit www.alltrna.com.

About The Role 

This is a unique opportunity to be a half lab/ half digital member of the Research Informatics team. You will be the bridge between bench researchers and Alltrna’s data systems and will help decide how the data generated by our wet bench teams are represented digitally. In addition, you will build pipelines and perform data migrations to ensure that these repositories are evolving with the new science that Alltrna explores.

The lab-based responsibilities will cover all aspects our Next Generation Sample Management: in vivo sample receipt, shipping, tracking, and internal/external inventory management to feed into our automated sample processing. In this capacity, you will interact with bench scientists, external vendors and CROs, and our lab operations group.

This role is ideal for someone with experience at the bench who is looking to lean into to their data skills. Alternatively, if you are considered a “superuser” of scientific software by your colleagues, this is your chance to turn that into a career.

Core Responsibilities 

Digital Responsibilities:

  • Maintain and customize the registry of research samples (either through point-and-click features or APIs) to support new data types and changes to the data model
  • Create the data model for how scientific samples (among others) will be represented digitally
  • Configure, administer, and train users on our ELN and LIMS (Benchling). Support users in executing data queries, output and formatting, running data and project dashboards
  • Additional: code data pipelines to reduce the need for manual data entry. Perform programmatic data migrations when changes to the data model take place
  • Additional: Based on user feedback/needs, input, and industry trends identify, demo, onboard new software systems as appropriate

Lab Responsibilities:

  • Own the logistics for shipping samples among Alltrna teams, external vendors, and offsite storage
    • Receive, reconcile and store/forward the incoming biological and test article samples
    • Maintain both physical and electronic records for sample storage, location and disposition
  • Draft protocols related to sample management
    • Maintain both physical and electronic records for sample storage, location and disposition
    • Additional: Manage data transfer agreements with external parties
  • Additional: process incoming samples in collaboration with other scientists. Examples of sample processing include:
    • Tissue homogenization
    • Perform nucleic acid extraction as well
    • DNA/RNA/protein quantification

Qualifications and Skills

  • Bachelors degree in the life sciences, training in computer science is a plus
  • Experience with Benchling or a similar ELN/LIMS; familiarity with data modelling concepts
  • 1-3 years experience working in a wet lab, specifically working with molecular biology and/or oligonucleotide chemistry
  • Demonstrated experience with biological sample handling including biological tissues
  • 6+ months experience with Python and SQL
  • Strong communication and people skills: demonstrated ability to listen to and collect user input, identify tools and capability gaps, and train users in processes
  • Demonstrated ability to work in a methodical and organized fashion and to document your work

What We’ll Offer You

  • Comprehensive, competitive healthcare and dental coverage through Blue Cross Blue Shield, vision coverage through VSP, family leave, paid time off, 401k retirement plan, disability and life insurance, and fully covered parking/commuter benefits.
  • A dynamic early-stage work environment and highly interdisciplinary, talented, and collaborative team.
  • Participation in an unprecedented opportunity to advance a single tRNA medicine to restore disrupted protein production, regardless of target, for thousands of diseases with the same underlying genetic mutation.
  • Professional growth opportunities through mentoring, training, immersion in cross-functional projects, and opportunities to learn and try new things.
  • Daily on-site snacks, cold brew coffee, and Bevi, as well as weekly catered lunches.

Our Core Values

  1. Fast-acting/efficient. Moves quickly and proactively with a strong work ethic to produce high-quality results while fostering a positive work environment. Focuses on key priorities. Demonstrates tenacity and willingness to go the distance to get something done.
  2. Integrity. Does not cut corners ethically. Earns trust and maintains confidences. Does what is right not just what is politically expedient. Speaks plainly and truthfully. Follows-through on commitments. Expects a high level of personal performance and team performance.
  3. Critical thinking. Learns quickly. Demonstrates ability to proficiently understand new information and independently achieve meaningful outcomes. Able to structure and process qualitative/quantitative data and draw insightful conclusions.
  4. Creativity & Innovation. Scientifically curious and bold. Generates new and creative approaches to problem solving. Positive ‘can-do’ attitude. Views the toughest challenges as the greatest opportunities for personal growth and company innovation. Able to challenge dogma.
  5. Teamwork. Fully engaged in facilitating personal and team success. Reaches out to peers and cooperates with the team to establish an overall collaborative work environment. Often solicits and responds well to constructive feedback. Possesses good written and oral communication skills with the ability to clearly and concisely convey ideas and opinions.
  6. Flexibility/adaptability. Adjusts quickly to changing strategic and tactical priorities. Comfortable with ambiguity. Self-starter mentality.
Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.
Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively, “FSP”) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneering’s internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP, and FSP will not owe any referral or other fees with respect thereto.

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