About Alltrna

Alltrna is the world’s first tRNA platform company to decipher tRNA biology and pioneer tRNA therapeutics to treat thousands of diseases. Alltrna unlocks tRNA biology to correct disease. The company's platform incorporates AI/ML tools to learn the tRNA language and deliver diverse programmable molecules with broad therapeutic potential. Alltrna has an unprecedented opportunity to advance a single tRNA medicine to unify treatment across a wide range of diseases with the same underlying genetic mutation. Alltrna was founded in 2018 by Flagship Pioneering. For more info, visit www.alltrna.com.

About The Role 

We are looking for a dynamic team player to join the growing chemical development team within our tRNA CMC Group. The candidate will work internally on the development of synthetic processes and purification systems to enable the manufacture of IND enabling toxicology studies and with external development partners on the cGMP manufacture of drug substances for clinical applications. In addition, the chemical development scientist will play a critical role in establishing our internal chemistry and purification lab capabilities, recruitment of staff and the design of tRNA drug substance manufacturing processes supporting Alltrna’s growing pipeline.

If you like a fast-paced, science driven research environment defining and developing manufacturing processes for an entirely new therapeutic modality- this is the role for you. You get to be part of the team that writes the playbook for how to make and characterize tRNA molecules and you will be critical not only in ensuring that we can understand how our manufacturing processes perform on scale-up but also in defining how we manufacture quality products for our clinical programs. We operate in an open and inclusive learning environment and need nimble thinkers who can chart courses and plan experiments based upon the data that we generate together. Flagship companies have a history of tackling difficult manufacturing challenges and developing innovative solutions to manufacture complex products- can you see yourself driving the science and engineering in this open space?     

Core Responsibilities

  • Support program teams with expertise on the development of synthetic and purification processes for oligonucleotides and drive manufacture of tRNA molecules for preclinical and clinical in vivo studies. Direct experience with solid-supported oligonucleotide synthesis and chromatographic purification techniques (RP-HPLC, AEX, UF/DF, etc.) in a fast-moving early development environment is essential

  • Manage chemical development projects with internal/external collaborators to drive innovative synthetic processes, novel amidite/raw material manufacture, and efficient purification processes. Special emphasis will be placed on application of Green Chemistry principles in process development and the control of impurities in our products.

  • Support cross functional teams to transfer drug substance processes to manufacturing partners (CMOs) including providing on-site technical support and troubleshooting during scale-up. Partner with analytical and formulations teams to drive an inclusive end-to-end development approach.

  • Contribute to the recruiting and growth of a team of scientists/engineers to develop synthetic and purification oligonucleotide manufacturing processes. Ability to provide direction, guidance, and mentoring to junior scientists/engineers.

  • Provide support to CMC teams and subject matter expertise for CMC sections of global regulatory filings.

Qualifications and Skills

  • PhD with 6+ years of direct experience in process chemistry, chemical development or manufacturing for biopharmaceutical applications (Chemical Engineering, Chemistry, Biochemical Engineering, or a related discipline)

  • Deep expertise in the synthesis and purification of oligonucleotide products and in drug substance development/cGMP manufacture. Proven track record of successful transfer of drug substance processes to CMO partners.

  • Expertise in using analytical characterization of impurity profiles, reaction dynamics, and design of experiments modeling (DOE) to support process development for pharmaceutical products.

  • Excellent written and verbal communication skills with emphasis on effective presentations and publications

  • Strong organizational skills and the ability to administer a project to ensure timely completions (including budgets, timelines, milestone tracking, etc.)

  • Highly skilled in Word, Excel, PowerPoint, and other tools. Knowledge of statistical software and applications for design of experiments and process modeling

What We’ll Offer You:

  • Comprehensive, competitive healthcare and dental coverage through Blue Cross Blue Shield, vision coverage through VSP, family leave, paid time off, 401k retirement plan, disability and life insurance, and fully covered parking/commuter benefits.
  • A dynamic early-stage work environment and highly interdisciplinary, talented, and collaborative team.
  • Participation in an unprecedented opportunity to advance a single tRNA medicine to restore disrupted protein production, regardless of target, for thousands of diseases with the same underlying genetic mutation.
  • Professional growth opportunities through mentoring, training, immersion in cross-functional projects, and opportunities to learn and try new things.
  • Get to be part of the team that writes the analytical playbook for developing tRNA molecules and you will be critical not only in ensuring that we can understand the impurity profiles of our tRNA molecules but also in defining how we build control strategies with chemists and engineers to drive manufacturing for our clinical programs.
  • Daily on-site snacks, cold brew coffee, and Bevi, as well as weekly catered lunches.

Our Core Values

Fast-acting/efficient. Moves quickly and proactively with a strong work ethic to produce high-quality results while fostering a positive work environment. Focuses on key priorities. Demonstrates tenacity and willingness to go the distance to get something done.

Integrity. Does not cut corners ethically. Earns trust and maintains confidences. Does what is right not just what is politically expedient. Speaks plainly and truthfully. Follows-through on commitments. Expects a high level of personal performance and team performance.

Critical thinking. Learns quickly. Demonstrates ability to proficiently understand new information and independently achieve meaningful outcomes. Able to structure and process qualitative/quantitative data and draw insightful conclusions.

Creativity & Innovation. Generates new and creative approaches to problem solving. Positive ‘can-do’ attitude. Views the toughest challenges as the greatest opportunities for personal growth and company innovation.

Teamwork. Fully engaged in facilitating personal and team success. Reaches out to peers and cooperates with the team to establish an overall collaborative work environment. Often solicits and responds well to constructive feedback. Possesses good written and oral communication skills with the ability to clearly and concisely convey ideas and opinions.

Flexibility/adaptability. Adjusts quickly to changing strategic and tactical priorities. Is comfortable ‘wearing multiple hats’.


Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

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