About Alltrna

Alltrna is the world’s first tRNA platform company to decipher tRNA biology and pioneer tRNA therapeutics to treat thousands of diseases. Alltrna unlocks tRNA biology to correct disease. The company's platform incorporates AI/ML tools to learn the tRNA language and deliver diverse programmable molecules with broad therapeutic potential. Alltrna has an unprecedented opportunity to advance a single tRNA medicine to unify treatment across a wide range of diseases with the same underlying genetic mutation. Alltrna was founded in 2018 by Flagship Pioneering. For more info, visit www.alltrna.com.

 About The Role 

Alltrna is seeking to hire a highly motivated and independent individual to join our fast-growing Pharmacology team and support pre-clinical programs. The successful candidate will particularly contribute to method development and bioanalytical tool implementation for in vitro/ex vivo studies. As part of a collaborative environment, the candidate will have the opportunity to acquire new skills and work closely with cross-functional teams. If you like a fast-paced, science driven research environment discovering how a new therapeutic modality can be shaped to meet the needs of patients suffering from serious underserved diseases- this is the role for you.

Core Responsibilities                                                                                                       

  • Design, execute and optimize the in vitro culture for established and primary patient cells
  • Contribute to the development, optimization, validation, and troubleshooting of bioanalytical methods to support pre-clinical programs in a matrix environment
  • Design, develop, optimize and execute in vitro cell-based assays such as Western, ELISA, MSD, RT-PCR, qPCR, and FACS, etc.
  • Perform transfection and measure biological activity of nucleic acid compounds
  • Analyze, interpret, and organize data to prepare clearly articulated experimental reports and present the results at internal meetings
  • Assume additional responsibilities as required

Qualifications and Skills

  • BS/ MS or PhD in cell biology, molecular biology, or a related discipline with 0 - 5 years of lab research experience, preferably in an industry setting (4 years for BS, 2 years for MS).
  • Extensive hands-on experience with mammalian cell culture techniques, including patient primary cells
  • Proven hands-on experience with cell-based analytical assays such as Western, ELISA, MSD, Luminex, RT-PCR, qPCR, flow cytometry, and high content imaging
  • Highly organized with strong attention to detail and multitasking skills, independently generating reliable data and analyzing the results in a timely manner
  • Excellent communication and presentation skills
  • Knowledge in data spreadsheets (Excel) and GraphPad Prism

The preferred candidate will ideally also possess the following skills:

  • Experience with in vitro culture of hepatocytes and fibroblasts is preferred
  • Experience with biological sample handling including processing various tissues is a plus
  • Experience of working with CROs is a plus

 What We’ll Offer You

  • Comprehensive, competitive healthcare and dental coverage through Blue Cross Blue Shield, vision coverage through VSP, family leave, paid time off, 401k retirement plan, disability and life insurance, and fully covered parking/commuter benefits.
  • A dynamic early-stage work environment and highly interdisciplinary, talented, and collaborative team.
  • Participation in an unprecedented opportunity to advance a single tRNA medicine to restore disrupted protein production, regardless of target, for thousands of diseases with the same underlying genetic mutation.
  • Professional growth opportunities through mentoring, training, immersion in cross-functional projects, and opportunities to learn and try new things.
  • Daily on-site snacks, cold brew coffee, and Bevi, as well as weekly catered lunches.

Our Core Values

  1. Fast-acting/efficient. Moves quickly and proactively with a strong work ethic to produce high-quality results while fostering a positive work environment. Focuses on key priorities. Demonstrates tenacity and willingness to go the distance to get something done.
  2. Integrity. Does not cut corners ethically. Earns trust and maintains confidences. Does what is right not just what is politically expedient. Speaks plainly and truthfully. Follows-through on commitments. Expects a high level of personal performance and team performance.
  3. Critical thinking. Learns quickly. Demonstrates ability to proficiently understand new information and independently achieve meaningful outcomes. Able to structure and process qualitative/quantitative data and draw insightful conclusions.
  4. Creativity & Innovation. Scientifically curious and bold. Generates new and creative approaches to problem solving. Positive ‘can-do’ attitude. Views the toughest challenges as the greatest opportunities for personal growth and company innovation. Able to challenge dogma.
  5. Teamwork. Fully engaged in facilitating personal and team success. Reaches out to peers and cooperates with the team to establish an overall collaborative work environment. Often solicits and responds well to constructive feedback. Possesses good written and oral communication skills with the ability to clearly and concisely convey ideas and opinions.
  6. Flexibility/adaptability. Adjusts quickly to changing strategic and tactical priorities. Comfortable with ambiguity. Self-starter mentality.

 

Flagship Pioneering and our ecosystem companies are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status.

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