Director, Program Management

Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using its proprietary platform to advance a pipeline of novel, tumor-activated clinical and preclinical I-O molecules that are designed to optimize their therapeutic index by localizing anti-tumor activity within the tumor microenvironment, including tumor-activated cytokines and antibodies (including bispecifics) and immune cell engagers (including tumor-activated cell engagers and tumor-activated effector-enhanced cell engagers). Learn more by visiting www.xiliotx.com and follow us on LinkedIn (Xilio Therapeutics, Inc.)

SUMMARY: 

Reporting to the SVP, Corporate Development and Program Leadership, the new position of Director, Program Management will be an essential part of supporting Xilio’s pre-clinical programs, clinical programs and CMC planning. Vital to the success of this role is effective program management that enables efficient and quality cross-functional execution of programs, fully owned and partnered. On occasion the person in this role may also be a supportive partner to the Senior Vice President pertaining to alliance management and/or business development activities.

This is a hybrid position, based in Waltham, MA, which offers an exciting opportunity to join a dynamic, small public biotech company dedicated to bringing potentially transformative therapies to cancer patients.

Job Responsibilities:

Provide program management expertise to Xilio programs, IND-enabling stage through late-clinical development stage.

  • Lead cross-functional program teams to execute the aligned program strategy.
  • Manage, monitor, track and communicate cross-functional program timelines, deliverables, budgets, agenda trackers, critical path, and cross program dashboards.
  • Develop agendas, document key discussion points and decisions, and distribute information as appropriate to key stakeholders.
  • Support integration, coordination and communication between alliance management, business development and program management activities as needed.
  • Support CMC planning and budgeting as part of overall program strategy and execution.
  • Proactively identify potential issues or risks proactively, and diplomatically collaborate with others to plan effective mitigation strategies.
  • Monitor issues through resolution and support communication to key stakeholders, ensuring they are informed of outcomes and program implications.
  • Proactively address and remove barriers to program progress, keeping leadership informed of critical considerations (e.g., resources, performance).
  • With the SVP’s guidance and support, resolve complex issues and competing priorities that may impact achievement of goals.
  • Enthusiastically play lead role and when organizing and coordinating work behind the scenes.

Skills, Qualifications, and Requirements:

  • BS required, ideally in a scientific/engineering discipline. Advanced degree preferred.
  • 7-10 years of related work experience in the life sciences industry, with 5-7 years of demonstrated program management experience working with cross-functional teams.
  • Biotech or biopharma experience required, with pre-commercial oncology experience strongly preferred
  • Strong knowledge of IND-enabling and early clinical stage development functional planning and interdependencies of relevant functions including manufacturing within the life sciences industry.
  • Experienced in working across multiple scientific and business areas of an organization, including stakeholders at all levels of the business up to the Executive Committee
  • Experienced in managing shifting responsibilities in a dynamic, cross-functional teamwork environment.  Ability to adapt to changes to project plans, and to quickly embrace and implement new strategies and tactics to accommodate these changes.
  • Excellent oral and written communication skills including ability to synthesize, analyze, prioritize, and distill complex information into clear and succinct summaries and recommendations.
  • Prior success in building sustainable relationships with internal and external stakeholders through engendering trust and collaborative behaviors.
  • PMP, or equivalent certification, preferred. 

Diversity, Equity and Inclusion

At Xilio Therapeutics, we foster a culture of equity, diversity and inclusion.  We consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law.  We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability who requires accommodation with the hiring process or to perform any essential functions of the position for which you are applying, please reach out to careers@xiliotx.com.

#LI-NM1

Apply for this Job

* Required
resume chosen  
Dropbox Google Drive
(File types: pdf, doc, docx, txt, rtf)
Cancel
cover_letter chosen  
Dropbox Google Drive
(File types: pdf, doc, docx, txt, rtf)
Cancel

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Xilio Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Voluntary Self-Identification of Disability

Form CC-305
Page 1 of 1
OMB Control Number 1250-0005
Expires 04/30/2026

Why are you being asked to complete this form?

We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years.

Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to:

  • Alcohol or other substance use disorder (not currently using drugs illegally)
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS
  • Blind or low vision
  • Cancer (past or present)
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or serious difficulty hearing
  • Diabetes
  • Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders
  • Epilepsy or other seizure disorder
  • Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome
  • Intellectual or developmental disability
  • Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD
  • Missing limbs or partially missing limbs
  • Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports
  • Nervous system condition, for example, migraine headaches, Parkinson’s disease, multiple sclerosis (MS)
  • Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities
  • Partial or complete paralysis (any cause)
  • Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema
  • Short stature (dwarfism)
  • Traumatic brain injury

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.

Enter the verification code sent to to confirm you are not a robot, then submit your application.

This application was flagged as potential bot traffic. To resubmit your application, turn off any VPNs, clear the browser's cache and cookies, or try another browser. If you still can't submit it, contact our support team through the help center.