Principal Scientist, Mass Spectrometry

Xilio Therapeutics is a clinical-stage biotechnology company discovering and developing tumor-activated immuno-oncology (I-O) therapies with the goal of significantly improving outcomes for people living with cancer without the systemic side effects of current I-O treatments. The company is using its proprietary platform to advance a pipeline of novel, tumor-activated clinical and preclinical I-O molecules that are designed to optimize their therapeutic index by localizing anti-tumor activity within the tumor microenvironment, including tumor-activated cytokines and antibodies (including bispecifics) and immune cell engagers (including tumor-activated cell engagers and tumor-activated effector-enhanced cell engagers). Learn more by visiting www.xiliotx.com and follow us on LinkedIn (Xilio Therapeutics, Inc.)

SUMMARY:

We are looking for a Principal Scientist to join our Mass Spectrometry Team. Their primary responsibility will be LC-MS based characterization and bioanalysis of therapeutic proteins, particularly multifunctional antibody and Fc fusion protein constructs. Additionally, the Principal Scientist works closely with other groups such as biologics, CMC, cell pharmacology and in vivo pharmacology to support their diverse mass spectrometry-based needs internally and with external partners. The Principal Scientist will have tremendous opportunities within a dynamic, enthusiastic, highly interdisciplinary and collaborative team.

Job Responsibilities:

Manage LC-MS analysis of therapeutic proteins to support Biologics production/characterization and CMC including but not limited to: intact mass analysis, peptide mapping and PTM profiling
Utilize LC-MS/MS to perform non-GLP bioanalytical quantitation method development, qualification and sample analysis for therapeutic proteins to support non-GLP pharmacology studies
Coordinate and assist in managing outsourced work from characterization to bioanalysis at CROs
Manage and troubleshoot LC-MS systems in the facility
Mentor and train junior colleagues
Identify and integrate technologies that improve or expand the ability to LC-MS analysis by working with teammates, collaborators, vendors, and staying abreast of the literature
Contribute to document and report writing to support regulatory submissions (IND, etc)
Enter all data into electronic laboratory notebooks and databases on a daily basis, generate weekly summary reports for management review
Actively participate and present data and analyses at project team and department meetings; represent function in project meetings

Skills, Qualifications, and Requirements:

Ph.D. in Chemistry or Biochemistry or a relevant scientific discipline with 4+ years of biopharma experience or MS with 7+ years of biopharma experience
Essential to possess technical expertise in the LC-MS analysis of proteins, specifically protein characterization; additional skills in protein bioanalytical quantitation are a plus.
Previous experience managing direct reports is a plus
Hands-on experiences are necessary, including sample preparation (Affinity Capture, SPE, Protein Precipitation, etc), LC-MS operation, basic maintenance and troubleshooting
Skills with the following are a plus: SDS-PAGE, and HPLC (IEX, SEC etc)
Experience with immune oncology and/or protease biology is a plus
A track record of innovation and scientific rigor, strong problem solving and troubleshooting skills, and ability to contribute constructively to discussions
Goal oriented, organized, capable of prioritizing and working on multiple projects, and able to execute to timelines that meet company goals
Work well in a cross functional team environment, both independently as well as be willing to help others
Good verbal and written communication skills
Driven by a desire to create the next generation of immunotherapy-based cancer therapeutics and the vision to offer cancer patients efficacious and tolerable new therapies that extend and improve their lives.

Diversity, Equity and Inclusion

At Xilio Therapeutics, we foster a culture of equity, diversity and inclusion. We consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law. We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability who requires accommodation with the hiring process or to perform any essential functions of the position for which you are applying, please reach out to careers@xiliotx.com.

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