The Company

Welcome to Aetion! Since our debut in 2013, we have grown into one of the country’s leading science-driven technology companies using real-world evidence to provide innovative healthcare solutions.

We achieve this with our Aetion Evidence Platform, a software platform used to evaluate the safety, effectiveness and value of medications, delivering better outcomes to patients, medical professionals and clients.  We’ve partnered with top biopharma companies and are backed by leading venture capital firms to help further expand our research and product line.

To continue our mission to transform healthcare, we’re assembling a team of talented individuals who know how to work collaboratively and authentically, to innovate and think transformation, not status quo. 

If that’s you, we’d love to hear from you.


As a Senior Principal Scientist, you will advance science within the organization, in product offerings, with clients, and with key external audiences such as regulators and standards bodies; be a thought-leader and Principal Investigator, driving original Aetion-initiated research projects and collaborations with key stakeholders; provide consultation to client engagement teams for studies with complex methodology or regulatory involvement. Reports to the Head of Research Strategy or Head of Scientific Strategy.


Scientific Research & Thought Leadership      

  • Serve as Principal Investigator on research questions initiated internally or in collaboration with external organizations (e.g., academic, government).
  • Serve as scientific subject matter expert in interactions with regulatory agencies, HTAs, clients and partners.
  • Be active in external thought-leadership including submission of conference abstracts, authorship of manuscripts, participation in regulatory events, workshops and webinars, involvement with professional societies, and teaching.
  • Maintain a strong and current knowledge base in pharmacoepidemiology, HEOR, and/or biostatistical methods as applied to observational RWE studies.
  • Serve as an internal resource to Delivery teams and other functions in promoting educational activities and knowledge sharing, development of best practice documents, and providing scientific review of relevant content (e.g., protocols, reports).
  • Serve as scientific advisor, mentor and teacher to internal scientists to further their career growth and scientific knowledge.


  • Manage a small team of Principal Scientists and Research Analysts to lead key scientific projects and support the activities described above and below.
  • Work closely with the Heads of Research Strategy and Scientific Strategy and other senior Aetion leaders, on topics including scientific strategy, long-term growth, policy and AEP direction.

Cross-Collaboration Across Teams

  • Develop a deep understanding of the methodological capabilities of the Aetion Evidence Platform, work cross-collaboratively to identify priorities for feature enhancements, and help identify appropriate methods for new analytic AEP features and develop detailed technical specifications for the Product and Engineering teams.
  • Provide thought-leadership cross-functionally to establish research and methods priorities.
  • Serve as internal consultant to team members and clients on methodologic issues, regulatory matters, and/or payer perspectives.
  • Provide critical scientific review of submissions to conferences, manuscripts, and reports, and other external-facing content (e.g., marketing materials, press releases, etc.).
  • Support external growth efforts as a subject matter expert.


Degree/experience requirements

  • Doctorate degree in epidemiology with at least 5 years of experience in a research or analytic area following degree completion; or
  • In exceptional circumstances, master’s degree in epidemiology, statistics, or a related analytic field with at least 8 years of experience in a research or analytic area following degree completion and demonstrated proficiency in core competencies.

Core competency requirements

  • Strong knowledge base in the principled application of pharmacoepidemiologic research methods to yield real-world evidence (RWE) for decision-making.
  • Understanding of analysis approaches, analytical and software tools (e.g., R, Aetion Evidence Platform), and computing environments.
  • Experience working with multiple types of healthcare databases relevant to pharmacoepidemiology/HEOR (claims, EMR, US and non-US, registries, etc.)
  • Direct experience working for (or with) regulatory bodies such as FDA and/or EMA, and on regulatory submissions.
  • Proficient presenter to scientific audiences.
  • Strong ability to provide strategic advice, innovate and implement fit for purpose solutions.
  • Strong ability to manage and mentor junior colleagues, including providing critical feedback and fostering career development.
  • Extensive track record of substantive publications and high impact presentations (workshops/symposia/panels/course leadership) at scientific conferences.
  • Experience conducting quantitative analyses using a programming language.
  • Therapeutic area experience, such as oncology, immunology or rare diseases.
  •  Excellent analytical and problem-solving skills.
  • Strong ability to self-motivate and manage conflicting priorities in a fast-paced environment

About Aetion

  • Lead at all levels – Aetion is a diverse workforce of scientific thought leaders and technological innovators coming together with a vision to dramatically improve the Healthcare industry.  Aetion supports and maintains a presence in organizations such as ISPOR, ISPE, ASHP, and HIMSS
  • Located in three cities — We have offices located in Midtown Manhattan near Penn Station, Boston's financial district, and Los Angeles. All locations are accessible by various forms of public transportation.
  • Social and energetic offices – with a modern layout, and a giant kitchen and eating/social area. We have an open floor plan with an abundance of conference rooms, designed for impromptu collaboration, company gatherings, and industry meetups and events. 
  • Great perks – We offer competitive salaries, top-of-the-line benefits, company ownership stock options, 4% 401(k) match, and unlimited PTO
  • Awards – Aetion is the recipient of numerous prestigious awards: 

Aetion is an Equal Opportunity Employer. Aetion is committed to being an employer of choice, not just a good place to work, but a great and inclusive place to work. To that end, we strive to recruit and maintain a workforce that meaningfully represents the diverse and culturally rich communities that we serve. Qualified applicants will receive consideration for employment without regard to their race, color, religion, national origin, sex, sexual orientation, gender identity, protected veteran status or disabled status or, genetic information.

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