About Abalone Bio

Abalone Bio is a San Francisco Bay Area, preclinical-stage biotechnology company developing antibody drugs for G protein-coupled receptors (GPCRs), ion channels and other membrane protein targets. We are developing our own therapeutics as well as partnering with pharmaceutical companies to discover drug candidates for their targets. 

 

At the core of our company is a functional antibody discovery platform comprising a synthetic biology-powered cell-based enrichment component and an NGS-powered computational selection component. We directly search for antibodies that can modulate the function of receptor targets, rather than first finding binders and then screening that subset for function. We find ultra-rare antibodies that have unique functional properties that enable us to address previously untreatable diseases.

 

Who are we looking for? 

You will join a small cross-functional R&D team and work closely with other Abalone Bio team members.  You will leverage your deep background to optimize Abalone Bio’s antibody selection platform, finding efficiencies at all steps of the process.  You will provide scientific and technical leadership and collaborate with project teams while working on complex problems.  You have the ability to quickly learn and develop new techniques and methods and synthesize complex data sets.  You leverage creative thinking to propose and advocate new ideas, make connections, and solve problems.  You excel in a fast-paced, team-oriented start-up environment and enjoy the challenge of working on multiple projects and wearing many hats. 

 

Responsibilities 

  • Develop, test and implement optimizations to Abalone Bio’s antibody selection technology (biological and computational aspects)
  • Develop and perform yeast cell-based selections for functional antibodies against membrane targets
  • Develop high-throughput assays for antibody validation and characterization in yeast and mammalian cells
  • Design, construct and characterize antibody libraries
  • Generate and analyze NGS data for identification of functional antibody hits
  • Support team by providing subject matter expertise; maintain knowledge of scientific trends, industry processes and target literature
  • Effectively communicate with the team and external collaborators
  • Document all procedures accurately and in a timely manner
  • Mentor and train junior team members

 

Qualifications

  • PhD in Molecular Biology, Microbiology, Immunology or a related field with 1-2 years of experience, industry preferred (Scientist), or 3-5 years of industry experience (Sr. Scientist); MS in Molecular Biology, Microbiology, Immunology or a related field with 8+ years of industry experience
  • Experience optimizing complex processes
  • Deep background in microbial genetic engineering and microbiology 
  • Experience developing and performing selections and screens 
  • Developing, validating, and troubleshooting cell-based and biochemical assays 

 

Huge plus (but not required):

  • NGS sequencing and analysis
  • Background in GPCR signaling, G proteins, and related science
  • Working experience with S. cerevisiae
  • Microscopy and flow cytometry
  • Antibody library design
  • Antibody or protein engineering, production, purification, and analysis
  • Bioinformatics
  • Data analysis using R or other analytical tools; scripting in Unix or Python; development of new computational workflows

We are driven by making an impact on patient lives.  We seek team members who thrive in a team environment emphasizing respect, inclusiveness, crisp logic, creativity and openness.  

Abalone Bio offers compensation commensurate with qualifications, including competitive salary, stock options, health, dental and vision coverage, and a retirement plan.  Legal authorization to work in the U.S. is required.  Abalone Bio may agree to sponsor an individual for an employment visa now or in the future if there is a shortage of individuals with particular skills for this job.  In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and to complete the required employment eligibility verification form upon hire.  This position is for our Emeryville, CA location. 

Apply for this Job

* Required
  
Attach Dropbox Google Drive Paste
  
Attach Dropbox Google Drive Paste
When autocomplete results are available use up and down arrows to review
+ Add Another Education

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in Abalone Bio’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

1Section 503 of the Rehabilitation Act of 1973, as amended. For more information about this form or the equal employment obligations of Federal contractors, visit the U.S. Department of Labor's Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.