About the role:

We are seeking a Senior Scientist to join the Process Development team to lead the development of oligonucleotide synthesis, purification, characterization and QC strategies, methods, and processes for transfer to manufacturing. This is a unique cross-disciplinary position that will work closely with a variety of groups including Chemistry, Molecular Biology, Manufacturing Systems Engineering, Manufacturing, and QC.

Candidates must have extensive experience in both process development and oligonucleotide manufacturing with a deep understanding of the underlying chemistry involved. The candidate will utilize proven design of experiment (DOE) principals to optimize all physical, chemical, and environmental aspects of the synthesis and purification methods to ensure the processes developed are efficient, high-yielding, reliable, and robust prior to documenting them and transferring to manufacturing. It is critical that appropriate in-line controls, monitoring, and QC methods are established, validated, and implemented to guarantee processes remain in control and any excursions from nominal values are identified early in the production cycle.    

Individuals applying for this position must be creative, passionate, detail-oriented self-starters who thrive in a fast-paced environment through actions driven by strategic thinking. In addition, successful candidates will be flexible in changing direction and approaches, excel at managing multiple priorities, succeed in communicating with all levels within the organization, and provide immediate contribution.


What you will be doing:

  • Leading the conception, development, and optimization of robust, high-throughput, plate-based oligonucleotide manufacturing methods and processes in preparation for transfer to production
  • Establishing suitable purification processes for diverse classes of oligonucleotides with varying physical properties at different scales
  • Planning and performing systematic workflow and reagent optimization by modeling, guard band studies, identification of critical factors, and use of formal design of experiment (DOE) approaches. This includes in-depth analysis and reporting of your data through documentation and presentations to internal groups.
  • Identifying and optimizing any compounding factors, such as temperature, environment, workflow, pressures, reagent concentrations, etc. that could impact the resulting product
  • Developing and validating new QC methods to assess the suitability, stability, and functionality of a range of oligonucleotides through a variety of analytical and functional tests
  • Implementing routine process QC methods to ensure processes are in control
  • Identification and implementation of statistical process control tools
  • Verifying that the manufactured products output meets all predetermined requirements
  • Driving the technology transfer phase as new products move from process development into manufacturing in preparation for commercial launch
  • Installation and verification of equipment, documenting processes, and training operators
  • Independently troubleshooting and resolving reagent formulation, process, QC, and incoming material issues
  • Providing technical leadership in the production and analysis of oligonucleotides to identify continuous improvement opportunities
  • Guiding infrastructure requirements to build out internal oligonucleotide manufacturing capabilities
  • Working closely with computational and molecular biologists to interpret data generated by novel assays


Minimum Requirements:

  • PhD. in Chemistry, Biochemistry, Chemical Engineering, or related field
  • 3+ years industry experience in oligonucleotide manufacturing process development and/or manufacturing
  • Extensive experience with plate-based oligonucleotide synthesis instrumentation (e.g. Dr Oligo, Mermade) and subsequent plate-based downstream processing
  • Proven hands-on experience in the synthesis, purification, and QC of oligonucleotides as evidenced by peer-reviewed publications, published patents, or commercialized products
  • Expert technical knowledge of nucleotide modifications and oligonucleotide synthesis, purification, and QC methods, techniques, strategies, and equipment
  • Ability to meticulously design and execute on meaningful experiments and perform in-depth analyses of the resultant data. Experience using statistical tools, such as JMP, is beneficial.
  • Exceptionally strong troubleshooting and problem-solving skills
  • Ability to integrate a broad range of scientific and engineering disciplines
  • Experience developing and implementing novel QC methods to assess reagent performance in both functional and orthogonal assays
  • Proven track record of ability to develop, validate, and transfer processes to manufacturing or OEM vendors
  • Strong process transfer experience, demonstrating control of manufacturing processes through appropriate Process Design and QC methods
  • Proven ability to write SOPs and train others to successfully perform the work.
  • Strong organizational, collaboration, and written and oral communication skills
  • Desire to be part of a rapidly evolving organization with the ability to work in a fast-paced and quickly changing environment


Preferred Skills/Experience:

  • Experience in GMP, GLP setting and good documentation practices preferred
  • Experience using statistical tools, such as JMP to analyze complex data sets, create DOE experiments, and data trending
  • Previous work guiding the development of new manufacturing and production infrastructure
  • Experience operating liquid handling robots and other common laboratory automation tools, ability to program these instruments would be very beneficial




Below is the base pay range for this full time position.  The actual base pay will depend on several factors unique to each candidate, including one’s skills, qualifications, and experience.  At 10x, base pay is also just one component of the Company’s total compensation package.  This role is also eligible for 10x’s equity grants, its comprehensive health and retirement benefit programs, and its annual bonus program or sales incentive program.  Your 10x recruiter can share more about the Company’s total compensation package during the hiring process.

Pay Range
$152,100$185,900 USD

About 10x Genomics

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference. 

Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation, or any other characteristic protected by applicable law.

10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.

LI Image    Twitter Icon

Apply for this Job

* Required

resume chosen  
(File types: pdf, doc, docx, txt, rtf)
cover_letter chosen  
(File types: pdf, doc, docx, txt, rtf)

Voluntary Self-Identification

For government reporting purposes, we ask candidates to respond to the below self-identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file.

As set forth in 10x Genomics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law.

Race & Ethnicity Definitions

If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows:

A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service-connected disability.

A "recently separated veteran" means any veteran during the three-year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service.

An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense.

An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985.

Form CC-305

OMB Control Number 1250-0005

Expires 05/31/2023

Voluntary Self-Identification of Disability

Why are you being asked to complete this form?

We are a federal contractor or subcontractor required by law to provide equal employment opportunity to qualified people with disabilities. We are also required to measure our progress toward having at least 7% of our workforce be individuals with disabilities. To do this, we must ask applicants and employees if they have a disability or have ever had a disability. Because a person may become disabled at any time, we ask all of our employees to update their information at least every five years.

Identifying yourself as an individual with a disability is voluntary, and we hope that you will choose to do so. Your answer will be maintained confidentially and not be seen by selecting officials or anyone else involved in making personnel decisions. Completing the form will not negatively impact you in any way, regardless of whether you have self-identified in the past. For more information about this form or the equal employment obligations of federal contractors under Section 503 of the Rehabilitation Act, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at www.dol.gov/ofccp.

How do you know if you have a disability?

You are considered to have a disability if you have a physical or mental impairment or medical condition that substantially limits a major life activity, or if you have a history or record of such an impairment or medical condition.

Disabilities include, but are not limited to:

  • Autism
  • Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, or HIV/AIDS
  • Blind or low vision
  • Cancer
  • Cardiovascular or heart disease
  • Celiac disease
  • Cerebral palsy
  • Deaf or hard of hearing
  • Depression or anxiety
  • Diabetes
  • Epilepsy
  • Gastrointestinal disorders, for example, Crohn's Disease, or irritable bowel syndrome
  • Intellectual disability
  • Missing limbs or partially missing limbs
  • Nervous system condition for example, migraine headaches, Parkinson’s disease, or Multiple sclerosis (MS)
  • Psychiatric condition, for example, bipolar disorder, schizophrenia, PTSD, or major depression

PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete.